Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C14H20O7 |
| Molecular Weight | 300.3044 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@@H](OCCC2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=ILRCGYURZSFMEG-RKQHYHRCSA-N
InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18515456
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18515456
Salidroside (Rhodioloside) is a glucoside which was isolated in 1926 from Salix triandra L. (Salicaceae). It is thought to be one of the compounds responsible for the antidepressant and anxiolytic actions of this plant, along with rosavin. Also was investigated that salidroside may be a promising candidate for the treatment of inflammatory liver injury and promotes skeletal regeneration in cell-autonomous and cell-non-autonomous ways and might be a potential therapy for accelerating fracture healing.
CNS Activity
Sources: doi/10.1111/jnc.13225/pdf Retrived from | http://onlinelibrary.wiley.com/doi/10.1111/jnc.13225/pdf
Curator's Comment: Known to be CNS penetrant in mouse, rat. Human data not available
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. | 2001 Apr |
|
| Analysis of the marker compounds of Rhodiola rosea L. (golden root) by reversed phase high performance liquid chromatography. | 2001 Apr |
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| Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis. | 2001 Apr |
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| Salidroside from Rhodiola sachalinensis protects neuronal PC12 cells against cytotoxicity induced by amyloid-beta. | 2003 Aug |
|
| Phenolic components of Olea europaea--isolation of tyrosol derivatives. | 2004 Feb |
|
| [Protective effects of salidroside on injury induced by hypoxia/hypoglycemia in cultured neurons]. | 2004 May |
|
| [Effects of salidroside on carbohydrate metabolism and differentiation of 3T3-L1 adipocytes]. | 2004 May |
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| Use of apple seed meal as a new source of beta-glucosidase for enzymatic glucosylation of 4-substituted benzyl alcohols and tyrosol in monophasic aqueous-dioxane medium. | 2004 May 3 |
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| [Effects of plant growth substances on induction and culture of callus from Rhodiola quadrifida]. | 2005 Aug |
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| Kinetic study of the physicochemical and microbiological changes in "seasoned" olives during the shelf-life period. | 2005 Jun 29 |
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| Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. | 2005 Oct |
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| The effect of salidroside on cell damage induced by glutamate and intracellular free calcium in PC12 cells. | 2006 Jan-Mar |
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| Evaluation of biologically active compounds in roots and rhizomes of Rhodiola rosea L. cultivated in Lithuania. | 2007 |
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| Effect of different preparation methods on physicochemical properties of salidroside liposomes. | 2007 Apr 18 |
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| Development of an HPLC method for the determination of salidroside in beagle dog plasma after administration of salidroside injection: application to a pharmacokinetics study. | 2007 Dec |
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| X-ray crystal structure and antioxidant activity of salidroside, a phenylethanoid glycoside. | 2007 Mar |
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| Simultaneous determination of salidroside and tyrosol in extracts of Rhodiola L. by microwave assisted extraction and high-performance liquid chromatography. | 2007 Nov 5 |
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| Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. | 2007 Sep |
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| Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation. | 2008 Dec |
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| Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats. | 2008 Oct 31 |
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| Salidroside inhibits H2O2-induced apoptosis in PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. | 2008 Sep |
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| Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway. | 2009 Apr 1 |
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| Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis. | 2009 Dec |
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| Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. | 2009 Jun |
|
| Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. | 2009 Jun 22 |
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| Effects of Radix et Rhizoma Rhodiolae Kirilowii on expressions of von Willebrand factor, hypoxia-inducible factor 1 and vascular endothelial growth factor in myocardium of rats with acute myocardial infarction. | 2009 May |
|
| Salidroside, the main active compound of Rhodiola plants, inhibits high glucose-induced mesangial cell proliferation. | 2009 Sep |
|
| Biosynthesis of acteoside in cultured cells of Olea europaea. | 2010 Apr |
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| Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. | 2010 Jul 16 |
Sample Use Guides
in mice: C57BL/6 mice were orally administrated salidrosid for continuous 5 days, followed by three gavages of ethanol every 30 min
Route of Administration:
Oral
In Vitro Use Guide
Curator's Comment: Pretreatment of the human umbilical vein endothelial cells (HUVECs) with Salidroside (SAL) significantly reduced the cell damage effects brought by homocysteine (Hcy) in a dose-dependent manner. Functional studies on the HUVECs found that SAL rescued the endoplasmic reticulum stress induced by Hcy. The underlying mechanisms involve the inhibition of Hcy-induced activation of binding protein (Bip) and C/EBP homologous protein (CHOP), as well as the phosphorylation of protein kinase RNA-like ER kinase (PERK) or inositol-requiring enzyme 1 alpha (IRE1α).
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1609534
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741643
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10338-51-9
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DTXSID4049034
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M983H6N1S9
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Rhodioloside
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159278
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SUBSTANCE RECORD
