FLUTRICICLAMIDE F-18

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H27FN2O2
Molecular Weight	345.4415
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)C(=O)[C@H]1CCCC2=C1C3=C(OC)C=CC=C3N2CC[18F]

InChI

InChIKey=ZVDVQPLDTTXLKI-LSKWOKDISA-N

InChI=1S/C20H27FN2O2/c1-4-22(5-2)20(24)14-8-6-9-15-18(14)19-16(23(15)13-12-21)10-7-11-17(19)25-3/h7,10-11,14H,4-6,8-9,12-13H2,1-3H3/t14-/m0/s1/i21-1

HIDE SMILES / InChI

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT02350426 | https://www.ncbi.nlm.nih.gov/pubmed/27261523

Flutriciclamide F18 (18F-GE-180), a translocator protein (TSPO)-PET radiotracer was used using in different pathologies. This agent was studied in phase I clinical trial to assess inflammation in rheumatoid arthritis. However, this study was terminated because of the pre-defined stopping criteria in the protocol.

Approval Year

PubMed

Title	Date	PubMed
Neuroinflammation Appears Early on PET Imaging and Then Plateaus in a Mouse Model of Alzheimer Disease.	2018-03	28986511
Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein.	2016-11	27261523
In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice.	2015-11-25	26609163

Patents

Sample Use Guides

In Vivo Use Guide

18F-GE-180 solution for IV injection in 10mL glass vial. Patients will receive a maximum activity of 195 MBq in a maximum volume of 10 mL (bolus) of 18F-GE-180, containing not more than 2 microgram (mcg)/mL 18F-GE-180 (20 mcg for a 10 mL dose).

Route of Administration: Intravenous

Name

Type

Language

FLUTRICICLAMIDE (18F)

Preferred Name

English

FLUTRICICLAMIDE F-18

Common Name

English

1H-CARBAZOLE-4-CARBOXAMIDE, N,N-DIETHYL-9-(2-(FLUORO-18F)ETHYL)-2,3,4,9-TETRAHYDRO-5-METHOXY-, (4S)-

Systematic Name

English

Flutriciclamide (18F) [WHO-DD]

Common Name

English

GE-180 F-18

Code

English

18F-GE-180

Code

English

flutriciclamide (¹?F) [INN]

Common Name

English

Code System Code Type Description

PUBCHEM

51040949