Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H21N5O3S |
| Molecular Weight | 447.51 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(CNC(=O)C2=CC(=NC=C2C3=NC=CS3)C4=CN=CC(C)=C4)N=C1OC
InChI
InChIKey=VSOUDUXMPUHJEU-UHFFFAOYSA-N
InChI=1S/C23H21N5O3S/c1-14-8-15(11-24-10-14)19-9-17(18(13-26-19)23-25-6-7-32-23)21(29)27-12-16-4-5-20(30-2)22(28-16)31-3/h4-11,13H,12H2,1-3H3,(H,27,29)
Approval Year
Funbound
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
4% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25248679/ |
MK-3697 plasma | Homo sapiens population: age: ADULT sex: food status: |
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| Code System | Code | Type | Description | ||
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MK-3697
Created by
admin on Sat Dec 16 18:32:20 GMT 2023 , Edited by admin on Sat Dec 16 18:32:20 GMT 2023
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PRIMARY | MedKoo CAT NO: 510214, CAS NO: 1224846-01-8Description: MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists . MK-3697 is also the third insomnia drug, currently being developed by Merck. MK-3697 has Ki = 0.95 nM. Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia. In vivo tests results on MK-3697 demonstrated improved stability and TDI profiles as well as excellent sleep efficacy across species. (Last updated: 8/6/2015). | ||
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46190695
Created by
admin on Sat Dec 16 18:32:20 GMT 2023 , Edited by admin on Sat Dec 16 18:32:20 GMT 2023
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PRIMARY | |||
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M8238285OA
Created by
admin on Sat Dec 16 18:32:20 GMT 2023 , Edited by admin on Sat Dec 16 18:32:20 GMT 2023
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PRIMARY | |||
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1224846-01-8
Created by
admin on Sat Dec 16 18:32:20 GMT 2023 , Edited by admin on Sat Dec 16 18:32:20 GMT 2023
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PRIMARY |
ACTIVE MOIETY
