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Details

Stereochemistry ABSOLUTE
Molecular Formula C24H21Cl2FN4O
Molecular Weight 471.354
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BMS-394136

SMILES

CC1=C([C@H](N2N=CC=C2N1)C3=CC=C(Cl)C(Cl)=C3)C(=O)N4CCC[C@H]4C5=CC=C(F)C=C5

InChI

InChIKey=LADJRPDOKVCQCG-NZQKXSOJSA-N
InChI=1S/C24H21Cl2FN4O/c1-14-22(24(32)30-12-2-3-20(30)15-4-7-17(27)8-5-15)23(31-21(29-14)10-11-28-31)16-6-9-18(25)19(26)13-16/h4-11,13,20,23,29H,2-3,12H2,1H3/t20-,23+/m0/s1

HIDE SMILES / InChI
Bristol-Myers Squibb developed BMS-394136, as a selective IKur inhibitor for the treatment of arrhythmias. IKur is a repolarizing K+ current encoded by the KCNA5 gene and is expressed predominantly in the atrium of human. IKur is a potential atrial-selective target for the treatment of atrial fibrillation. Atrial selectivity and safety of BMS-394136 were studied in phase I clinical trial in patients with heart diseases. However, further, development has been discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Antiarrhythmic drugs for atrial fibrillation: Imminent impulses are emerging.
2018 Dec

Sample Use Guides

Oral Solution, Oral, 100 mg, Single dose, 1 day.
Route of Administration: Oral
Name Type Language
BMS-394136
Common Name English
METHANONE, ((7R)-7-(3,4-DICHLOROPHENYL)-4,7-DIHYDRO-5-METHYLPYRAZOLO(1,5-A)PYRIMIDIN-6-YL)((2S)-2-(4-FLUOROPHENYL)-1-PYRROLIDINYL)-
Systematic Name English
Code System Code Type Description
PUBCHEM
135446049
Created by admin on Sat Dec 16 01:54:36 GMT 2023 , Edited by admin on Sat Dec 16 01:54:36 GMT 2023
PRIMARY
FDA UNII
M694U7167K
Created by admin on Sat Dec 16 01:54:36 GMT 2023 , Edited by admin on Sat Dec 16 01:54:36 GMT 2023
PRIMARY
DRUG BANK
DB12067
Created by admin on Sat Dec 16 01:54:36 GMT 2023 , Edited by admin on Sat Dec 16 01:54:36 GMT 2023
PRIMARY
CAS
343246-73-1
Created by admin on Sat Dec 16 01:54:36 GMT 2023 , Edited by admin on Sat Dec 16 01:54:36 GMT 2023
PRIMARY
CAS
1411726-07-2
Created by admin on Sat Dec 16 01:54:36 GMT 2023 , Edited by admin on Sat Dec 16 01:54:36 GMT 2023
NO STRUCTURE GIVEN