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Details

Stereochemistry RACEMIC
Molecular Formula C26H36N2O3
Molecular Weight 424.5756
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEVAPAMIL

SMILES

COC1=CC=CC(CCN(C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)=C1

InChI

InChIKey=VMVKIDPOEOLUFS-UHFFFAOYSA-N
InChI=1S/C26H36N2O3/c1-20(2)26(19-27,22-11-12-24(30-5)25(18-22)31-6)14-8-15-28(3)16-13-21-9-7-10-23(17-21)29-4/h7,9-12,17-18,20H,8,13-16H2,1-6H3

HIDE SMILES / InChI
In the early stages of testing was shown that it is about 4 times more potent than gallopamil and 12 times more potent than verapamil in its effects on smooth muscle tone and labeled calcium uptake.

Approval Year

PubMed

PubMed

TitleDatePubMed
Opposite effects of a single IIIS5 mutation on phenylalkylamine and dihydropyridine interaction with L-type Ca2+ channels.
2004 Dec 31
L-type Ca2+ channel antagonists block voltage-dependent Ca2+ channels in identified leech neurons.
2004 Jul 9
Pharmacophoric features and Ca2+ ion holding capacity of verapamil.
2005 Dec 15
Investigation of the phenylalkylamine binding site in hKv1.3 (H399T), a mutant with a reduced C-type inactivated state.
2005 Oct
Structural model for phenylalkylamine binding to L-type calcium channels.
2009 Oct 9
Name Type Language
DEVAPAMIL
INN  
INN  
Official Name English
DESMETHOXYVERAPAMIL
Common Name English
BENZENEACETONITRILE, 3,4-DIMETHOXY-.ALPHA.-(3-((2-(3-METHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-.ALPHA.-(1-METHYLETHYL)-
Systematic Name English
2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-5-((M-METHOXYPHENETHYL)METHYLAMINO)VALERONITRILE
Systematic Name English
(±)-DEVAPAMIL
Common Name English
devapamil [INN]
Common Name English
D 888
Code English
DEVAPAMIL, (±)-
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C333
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID60869094
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
FDA UNII
M6142PTV7J
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
CHEBI
34673
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
EVMPD
SUB07015MIG
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
SMS_ID
100000083217
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
PUBCHEM
65832
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
INN
5696
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
ChEMBL
CHEMBL2074792
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
NCI_THESAURUS
C77823
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
WIKIPEDIA
Devapamil
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
CAS
92302-55-1
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
PRIMARY
CAS
102268-75-7
Created by admin on Fri Dec 15 16:22:25 GMT 2023 , Edited by admin on Fri Dec 15 16:22:25 GMT 2023
SUPERSEDED