Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H6N4O4S |
| Molecular Weight | 182.158 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=O)NS(=O)(=O)NC(N)=O
InChI
InChIKey=NRCPVGIMMWPWGT-UHFFFAOYSA-N
InChI=1S/C2H6N4O4S/c3-1(7)5-11(9,10)6-2(4)8/h(H3,3,5,7)(H3,4,6,8)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Identification and pharmacological correction of a membrane trafficking defect associated with a mutation in the sulfonylurea receptor causing familial hyperinsulinism. | 2001-09-21 |
|
| Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain. | 2001-09-07 |
|
| The Arabidopsis thaliana ABC protein superfamily, a complete inventory. | 2001-08-10 |
|
| Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. | 2001-08 |
|
| Serum nonesterified fatty acids are related with carotid atherosclerotic plaque in nonobese nonhypertensive Japanese type 2 diabetic patients. | 2001-08 |
|
| Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment. | 2001-08 |
|
| Utilization of oral hypoglycemic agents in a drug-insured U.S. population. | 2001-08 |
|
| Acute and short-term administration of a sulfonylurea (gliclazide) increases pulsatile insulin secretion in type 2 diabetes. | 2001-08 |
|
| Behavioral and olfactory responses to prochloraz, bentazone, and nicosulfuron-contaminated flows in goldfish. | 2001-08 |
|
| Is the molecular composition of K(ATP) channels more complex than originally thought? | 2001-08 |
|
| Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. | 2001-07-25 |
|
| Molecular physiology of neuronal K-ATP channels (review). | 2001-07-21 |
|
| Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study. | 2001-07 |
|
| Oral agents for the treatment of type 2 diabetes mellitus: pharmacology, toxicity, and treatment. | 2001-07 |
|
| Relationship between ethnicity and glycemic control, lipid profiles, and blood pressure during the first 9 years of type 2 diabetes: U.K. Prospective Diabetes Study (UKPDS 55). | 2001-07 |
|
| Characterization of a mutant sulfonylurea receptor SUR2B with high affinity for sulfonylureas and openers: differences in the coupling to Kir6.x subtypes. | 2001-07 |
|
| Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide. | 2001-06-26 |
|
| NADH oxidase activity (NOX) and enlargement of HeLa cells oscillate with two different temperature-compensated period lengths of 22 and 24 minutes corresponding to different NOX forms. | 2001-06-20 |
|
| Molecular structure of the glibenclamide binding site of the beta-cell K(ATP) channel. | 2001-06-15 |
|
| Impact of sulfonylurea receptor 1 genetic variability on non-insulin-dependent diabetes mellitus prevalence and treatment: a population study. | 2001-06-01 |
|
| Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels. | 2001-06 |
|
| Management of type 2 diabetes. Evolving strategies for treatment. | 2001-06 |
|
| Application of coupled liquid chromatography-mass spectrometry in photolysis studies of the herbicide triflusulfuron-methyl. | 2001-06 |
|
| Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide. | 2001-06 |
|
| Unbalanced expression of 11p15 imprinted genes in focal forms of congenital hyperinsulinism: association with a reduction to homozygosity of a mutation in ABCC8 or KCNJ11. | 2001-06 |
|
| Glibenclamide effects on reperfusion-induced malignant arrhythmias and left ventricular mechanical recovery from stunning in conscious sheep. | 2001-06 |
|
| A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism. | 2001-06 |
|
| Effect of a series of novel sulphonylthioureas on glucose tolerance in the obese fa/fa Zucker rat. | 2001-05-31 |
|
| Cellular and biophysical evidence for interactions between adenosine triphosphate and P-glycoprotein substrates: functional implications for adenosine triphosphate/drug cotransport in P-glycoprotein overexpressing tumor cells and in P-glycoprotein low-level expressing erythrocytes. | 2001-05-19 |
|
| Effects of sulfonylurea derivatives on ischemia-induced loss of function in the isolated rat heart. | 2001-05-04 |
|
| Oral agents in the management of type 2 diabetes mellitus. | 2001-05-01 |
|
| [Current and future aspects of oral antidiabetic agents in type 2 diabetes]. | 2001-05 |
|
| [Diabetology at the threshold of the 21st century]. | 2001-05 |
|
| Amaranthus palmeri resistance and differential tolerance of Amaranthus palmeri and Amaranthus hybridus to ALS-inhibitor herbicides. | 2001-05 |
|
| Design, synthesis and biological evaluation of a sulfonylcyanoguanidine as thromboxane A2 receptor antagonist and thromboxane synthase inhibitor. | 2001-05 |
|
| Use of the ligand immunofunctional assay for human insulin-like growth factor ((IGF) binding protein-3 (IGFBP-3) to analyze IGFBP-3 proteolysis and igf-i bioavailability in healthy adults, GH-deficient and acromegalic patients, and diabetics. | 2001-05 |
|
| Insulinoma induced hypoglycemia in a type 2 diabetic patient. | 2001-04-30 |
|
| Degradation of imazosulfuron in soil. | 2001-04 |
|
| [Type 2 diabetes mellitus: Which place for thiazolidinediones in the therapeutic strategy?]. | 2001-04 |
|
| [Diabetes mellitus and ischemic cardiopathy: potential effects of the use of sulfonylureas]. | 2001-04 |
|
| Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion. | 2001-04 |
|
| Comments to: Yudkin J, Panahloo A, Stenhouwer C et al. (2000) the influence of improved glycaemic control with insulin and sulphonylureas on acute phase and endothelial markers in type II diabetic subjects. Diabetologia 43: 1099-1106. | 2001-04 |
|
| Comments to: Yudkin J, Panahloo A, Stenhouwer C et al. (2000) the influence of improved glycaemic control with insulin and sulphonylureas on acute phase and endothelial markers in type II diabetic subjects. Diabetologia 43: 1099-1106. | 2001-04 |
|
| Involvement of cytochrome P-450 enzyme activity in the selectivity and safening action of pyrazosulfuron-ethyl. | 2001-03 |
|
| Response of the bacteria and fungi of two soils to the sulfonylurea herbicide cinosulfuron. | 2001-03 |
|
| Clinical significance of the insulin resistance index as assessed by homeostasis model assessment. | 2001-02 |
|
| Effects of atrazine and nicosulfuron on freshwater microalgae. | 2001-01 |
|
| Oral hypoglycemic agents: insulin secretagogues, alpha-glucosidase inhibitors and insulin sensitizers. | 2001 |
|
| Comparison of the effects of three sulfonylureas on in vivo insulin action. | 2001 |
|
| Relationship between plasma soluble thrombomodulin levels and insulin resistance syndrome in type 2 diabetes: a comparison with von Willebrand factor. | 2001 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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M5112OW4K3
Created by
admin on Mon Mar 31 18:49:30 GMT 2025 , Edited by admin on Mon Mar 31 18:49:30 GMT 2025
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PRIMARY | |||
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35507-37-0
Created by
admin on Mon Mar 31 18:49:30 GMT 2025 , Edited by admin on Mon Mar 31 18:49:30 GMT 2025
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PRIMARY | |||
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DTXSID00881179
Created by
admin on Mon Mar 31 18:49:30 GMT 2025 , Edited by admin on Mon Mar 31 18:49:30 GMT 2025
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PRIMARY | |||
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104818
Created by
admin on Mon Mar 31 18:49:30 GMT 2025 , Edited by admin on Mon Mar 31 18:49:30 GMT 2025
|
PRIMARY |
SUBSTANCE RECORD
