HALOXAZOLAM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H14BrFN2O2
Molecular Weight	377.208
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HALOXAZOLAM

Structure Search

SMILES

FC1=CC=CC=C1C23OCCN2CC(=O)NC4=CC=C(Br)C=C34

InChI

InChIKey=XDKCGKQHVBOOHC-UHFFFAOYSA-N

InChI=1S/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)

HIDE SMILES / InChI

Description
Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1591

Haloxazolam is a GABA-A receptor agonist indicated for the treatment of anxiety. The drug is approved and marketed in Japan under the name Somelin.

CNS Activity

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38 Target ID: CHEMBL2109243 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1591	Agonist 2678

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anxiety 267 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1591 http://www.info.pmda.go.jp/downfiles/ph/GUI/430574_1124005C1032_1_06G.pdf	Primary		Approved 8429	SOMELIN Approved Use Unknown

PubMed

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

The drug is usually administered orally at bedtime at dose 5-10mg.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

HALOXAZOLAM

Official Name

English

SOMELIN

Brand Name

English

haloxazolam [INN]

Common Name

English

HALOXAZOLAM [JAN]

Common Name

English

HALOXAZOLAM [MI]

Common Name

English

HALOXAZOLAM [MART.]

Common Name

English

Haloxazolam [WHO-DD]

Common Name

English

10-BROMO-11B-(O-FLUOROPHENYL)-2,3,7,11B-TETRAHYDROOXAZOLO(3,2-D)(1,4)BENZODIAZEPIN-6(5H)-ONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1012

Created by admin on Fri Dec 15 16:52:38 GMT 2023 , Edited by admin on Fri Dec 15 16:52:38 GMT 2023

DEA NO.

2771

Created by admin on Fri Dec 15 16:52:38 GMT 2023 , Edited by admin on Fri Dec 15 16:52:38 GMT 2023

Code System Code Type Description

DRUG CENTRAL

1357

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EPA CompTox

DTXSID60866740

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PUBCHEM

3563

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NCI_THESAURUS

C83744

Created by admin on Fri Dec 15 16:52:38 GMT 2023 , Edited by admin on Fri Dec 15 16:52:38 GMT 2023

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WIKIPEDIA

Haloxazolam

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MESH

C018779

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MERCK INDEX

m5908

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Merck Index

INN

4295

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DRUG BANK

DB01476

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SMS_ID

100000083946

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EVMPD

SUB08010MIG

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ChEMBL

CHEMBL2104461

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CAS

59128-97-1

Created by admin on Fri Dec 15 16:52:38 GMT 2023 , Edited by admin on Fri Dec 15 16:52:38 GMT 2023

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FDA UNII

M448L2V8XP

Created by admin on Fri Dec 15 16:52:38 GMT 2023 , Edited by admin on Fri Dec 15 16:52:38 GMT 2023

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ACTIVE MOIETY


					M448L2V8XP