HALOXAZOLAM

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H14BrFN2O2
Molecular Weight	377.208
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=CC=C1C23OCCN2CC(=O)NC4=CC=C(Br)C=C34

InChI

InChIKey=XDKCGKQHVBOOHC-UHFFFAOYSA-N

InChI=1S/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)

HIDE SMILES / InChI

Description
Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1591

Haloxazolam is a GABA-A receptor agonist indicated for the treatment of anxiety. The drug is approved and marketed in Japan under the name Somelin.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38 Target ID: CHEMBL2109243 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1591	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anxiety 267 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1591 http://www.info.pmda.go.jp/downfiles/ph/GUI/430574_1124005C1032_1_06G.pdf	Primary		Approved 8429	SOMELIN Approved Use Unknown

PubMed

Title	Date	PubMed
Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems.	1983 Oct	6139494
[The behavior of 1,4-benzodiazepine drugs in the acidic media. I. Proton and carbon 13 nuclear magnetic resonance spectra of oxazolam, cloxazolam and haloxazolam in the acidic media].	1984 Jun	6150102
The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of flutazolam and haloxazolam in aqueous solution.	1986 Jan	2870816
Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine.	1999 Jan-Feb	10022210
Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra.	2003 Feb	12519461

Sample Use Guides

In Vivo Use Guide

The drug is usually administered orally at bedtime at dose 5-10mg.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

HALOXAZOLAM

Official Name

English

SOMELIN

Brand Name

English

haloxazolam [INN]

Common Name

English

HALOXAZOLAM [JAN]

Common Name

English

HALOXAZOLAM [MI]

Common Name

English

HALOXAZOLAM [MART.]

Common Name

English

Haloxazolam [WHO-DD]

Common Name

English

10-BROMO-11B-(O-FLUOROPHENYL)-2,3,7,11B-TETRAHYDROOXAZOLO(3,2-D)(1,4)BENZODIAZEPIN-6(5H)-ONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1012