HALOXAZOLAM

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H14BrFN2O2
Molecular Weight	377.208
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

FC1=C(C=CC=C1)C23OCCN2CC(=O)NC4=C3C=C(Br)C=C4

InChI

InChIKey=XDKCGKQHVBOOHC-UHFFFAOYSA-N

InChI=1S/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)

HIDE SMILES / InChI

Description

Haloxazolam is a GABA-A receptor agonist indicated for the treatment of anxiety. The drug is approved and marketed in Japan under the name Somelin.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38	Agonist 2,752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anxiety 275	Primary		Approved 8,583	SOMELIN

C_max

Value	Dose	Analyte	Population
48.3 ng/mL	5 mg single, oral	FLUBROMAZEPAM plasma	Homo sapiens
58.6 ng/mL	5 mg 1 times / day multiple, oral	FLUBROMAZEPAM plasma	Homo sapiens
14.3 ng/mL	5 mg 1 times / day multiple, oral	FLUBROMAZEPAM plasma	Homo sapiens

T_1/2

Value	Dose	Co-administered	Analyte	Population
42 h	5 mg single, oral		FLUBROMAZEPAM plasma	Homo sapiens
43.2 h	5 mg 1 times / day multiple, oral		FLUBROMAZEPAM plasma	Homo sapiens

Doses

Doses

Show entries

Dose	Population	Adverse events
10 mg 1 times / day multiple, oral Studied dose	healthy, ADULT

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PubMed

PubMed

Show entries

Title	Date	PubMed
Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine.	1999 Jan-Feb	10022210

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Sample Use Guides

In Vivo Use Guide

The drug is usually administered orally at bedtime at dose 5-10mg.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Show entries

Name

Type

Language

SOMELIN

Preferred Name

English

HALOXAZOLAM

Official Name

English

haloxazolam [INN]

Common Name

English

HALOXAZOLAM [JAN]

Common Name

English

HALOXAZOLAM [MI]

Common Name

English

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Classification Tree

Code System

Code

Antianxiety Agent

NCI_THESAURUS

C1012

Sec. 1308.11 Schedule IV.

DEA NO.

2771

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Show entries

Code System

Code

Type

Description

DRUG CENTRAL

1357

PRIMARY

EPA CompTox

DTXSID60866740

PRIMARY

PUBCHEM

3563

PRIMARY

NCI_THESAURUS

C83744

PRIMARY

WIKIPEDIA

Haloxazolam

PRIMARY

Showing 1 to 5 of 14 entries

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ACTIVE MOIETY


					M448L2V8XP

HALOXAZOLAM

SMILES

InChI

CNS Activity

Originator

Approval Year

Targets

Conditions

Cmax

T1/2

Doses

PubMed

Sample Use Guides

C_max

T_1/2