ATAPROST

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H32O4
Molecular Weight	348.4764
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C3CCCC3)[C@@]1([H])C\C(C2)=C\CCCC(O)=O

InChI

InChIKey=DKLGLHQHLFISGJ-YLBFUXKPSA-N

InChI=1S/C21H32O4/c22-19(15-6-2-3-7-15)10-9-17-18-12-14(5-1-4-8-21(24)25)11-16(18)13-20(17)23/h5,9-10,15-20,22-23H,1-4,6-8,11-13H2,(H,24,25)/b10-9+,14-5+/t16-,17+,18-,19+,20+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://adisinsight.springer.com/drugs/800002073

Ataprost (also known as ONO-41483; OP-41483), an epoprostenol agonist, participated in phase II clinical trials in Japan for the treatment patients with heart failure and myocardial ischemia. However, these trials were discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of a stable prostacyclin analog on experimental ischemic acute renal failure.	1988 Jul	3291800
Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483.	1998 Sep	9740185

Patents

Name

Type

Language

ATAPROST

Official Name

English

ataprost [INN]

Common Name

English

OP-41483

Code

English

(+)-(2E,3AS,4R,5R,6AS)-4-((1E,3S)-3-CYCLOPENTYL-3-HYDROXYPROPENYL)-3,3A,4,5,6,6A-HEXAHYDRO-5-HYDROXY-.DELTA.(SUP 2(1H),.DELTA.)-PENTALENEVALERIC ACID

Common Name

English

OP41483

Code

English

ONO41483

Code

English

ATAPROST ALFADEX [JAN]

Common Name

English

ONO-41483

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C78568