Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H25NO4 |
Molecular Weight | 367.4382 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)C1=CC=CC=C1C(=O)C2=CC=C(OCCN3CCCCC3)C=C2
InChI
InChIKey=NZHMAQSCHUSSSJ-UHFFFAOYSA-N
InChI=1S/C22H25NO4/c1-26-22(25)20-8-4-3-7-19(20)21(24)17-9-11-18(12-10-17)27-16-15-23-13-5-2-6-14-23/h3-4,7-12H,2,5-6,13-16H2,1H3
Pitofenone is a spasmolytic agent. It exerts anticholinesterase and antimuscarinic activities. Pitofenone is used to relieve pain and spasms of smooth muscles. Pitofenone is also used for the treatment of back pain, sprains, and strains. Pitofenone is used in combination along with fenpiverinium bromide, and metamizole sodium. The drug is currently sold in Eastern Europe and India under various trade names. The combined preparation possesses strong analgesic, spasmolytic, cholinolytic and anti-inflammatory effects on the smooth muscles predominantly of the gastrointestinal and urogenital tract. Indications are strong pain in gastric or intestinal colic, kidney and gallstones, and for painful menstruation. Pitofenone hydrochloride present in the combination exerts papaverin-like spasmolytic effect on the vascular and extra-vascular smooth muscles of the stomach, intestines, urinary tract, biliary tract, and uterus.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2331074 |
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Target ID: CHEMBL4768 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1777122 |
36.0 µM [Ki] | ||
Target ID: CHEMBL2094109 |
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NCI_THESAURUS |
C29698
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WHO-VATC |
QA03DA02
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WHO-ATC |
A03DA02
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121098
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3051
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SUB09946MIG
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DTXSID6048381
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2215
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M09N8K7YJY
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54063-52-4
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C015454
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CHEMBL2104821
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PITOFENONE
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C73177
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100000081703
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)