Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C25H31F2NO4.ClH |
Molecular Weight | 483.976 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)(CC1CC2=C(C1)C=CC=C2)NC[C@@H](O)COC3=C(F)C(F)=CC(CCC(O)=O)=C3
InChI
InChIKey=BQGSCEAKPBWIDI-VEIFNGETSA-N
InChI=1S/C25H31F2NO4.ClH/c1-25(2,13-17-9-18-5-3-4-6-19(18)10-17)28-14-20(29)15-32-22-12-16(7-8-23(30)31)11-21(26)24(22)27;/h3-6,11-12,17,20,28-29H,7-10,13-15H2,1-2H3,(H,30,31);1H/t20-;/m1./s1
Ronacaleret (SB-751689-A) is a calcium-sensing receptor antagonist. This orally administered compound has been evaluated as a drug for treatment of postmenopausal osteoporosis. By antagonizing calcium-sensing receptors on the surface of the parathyroid gland, ronacaleret triggers a transient release of the body's own stores of parathyroid hormone. In patients with osteoporosis, this may increase volumetric bone mineral. In a phase II clinical trial, bone mineral density at the lumbar spine increased. Cardiac disorders (2.3% of patients) and gastrointestinal disorders (>60% of patients) were reported as adverse events. Phase I studies have also been conducted to evaluate the impact of ronacaleret on mobilization of Hematopoietic stem cells (HSCs) and to measure changes in CD34+ cell counts.
Originator
Approval Year
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NCI_THESAURUS |
C78281
Created by
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300000042501
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CHEMBL1198855
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10345213
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SS-25
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DBSALT002379
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702686-96-2
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LZM2DSH251
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C81352
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DTXSID40220508
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ACTIVE MOIETY
SUBSTANCE RECORD