Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C17H18N2O4 |
Molecular Weight | 314.3358 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)C1(CC1)OC(=O)C2=CN=CN2[C@H](C)C3=CC=CC=C3
InChI
InChIKey=DRAFVCKNYNQOKR-GFCCVEGCSA-N
InChI=1S/C17H18N2O4/c1-12(13-6-4-3-5-7-13)19-11-18-10-14(19)15(20)23-17(8-9-17)16(21)22-2/h3-7,10-12H,8-9H2,1-2H3/t12-/m1/s1
MDCO 700 (formerly ABP 700) is hypnosedative and anaesthetic agent that was being developed by The Medicines Company for the induction of general anesthesia and procedural sedation. It is a positive allosteric modulator of the GABAA receptor. It is a second generation analogue of etomidate, developed to retain etomidate's beneficial haemodynamic and respiratory profile but diminishing its suppression of the adrenocortical axis. Infusions of ABP-700 showed a dose-dependent hypnotic effect, and did not cause severe hypotension, severe respiratory depression, or adrenocortical suppression. The drug development for anaesthesia has been discontinued.
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29793605
Curator's Comment: ABP-700 as a 7 min infusion is safe and generally well tolerated. Infusion rates of 100 ug/kg/minand aboveare associated with drug-induced unconsciousnesswith goodpreservation of spontaneous breathing. https://www.isaponline.org/application/files/1614/7976/4265/03_Meier_ISAP.pdf
Five cohorts involving 40 subjects received increasing infusion doses of ABP-700, propofol 60 ug kg-1 min-1 or placebo.
Route of Administration:
Intravenous
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LZ0835OW2M
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DB15411
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71481187
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1446482-29-6
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ACTIVE MOIETY