Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
[Na+]
InChI
InChIKey=FKNQFGJONOIPTF-UHFFFAOYSA-N
InChI=1S/Na/q+1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/27904181 | https://www.ncbi.nlm.nih.gov/pubmed/27382594http://www.hmdb.ca/metabolites/HMDB00588Curator's Comment: description was created based on several sources, including
https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27904181 | https://www.ncbi.nlm.nih.gov/pubmed/27382594http://www.hmdb.ca/metabolites/HMDB00588
Curator's Comment: description was created based on several sources, including
https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018
Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.
CNS Activity
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2331043 |
|||
Target ID: CHEMBL2095186 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | POTASSIUM HYDROXIDE Approved UseUsed as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office. Launch Date2010 |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Kayexalate Approved UseINDICATION AND USAGE
Kayexalate is indicated for the treatment of hyperkalemia. Launch Date1958 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency. | 1972 |
|
| Delayed cystitis due to cyclophosphamide. | 1979 Jan 4 |
|
| A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k. | 1993 Mar 30 |
|
| Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. | 1994 Dec 20 |
|
| Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism. | 1994 Dec 20 |
|
| Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation. | 1994 Sep 30 |
|
| Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. | 1997 Aug 15 |
|
| Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts. | 1997 Feb |
|
| One-electron reduction of chromium(VI) by alpha-lipoic acid and related hydroxyl radical generation, dG hydroxylation and nuclear transcription factor-kappaB activation. | 1997 Feb 15 |
|
| Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line. | 1997 Nov |
|
| Reactive oxygen species regulate macrophage scavenger receptor type I, but not type II, in the human monocytic cell line THP-1. | 1998 Jun |
|
| Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. | 1998 Mar 6 |
|
| Molecular characterization of a broad selectivity neutral solute channel. | 1998 Sep 18 |
|
| Effect of beta-blockers on free radical-induced cardiac contractile dysfunction. | 1999 Jul 27 |
|
| Different protective roles in vitro of alpha- and beta-domains of growth inhibitory factor (GIF) on neuron injuries caused by oxygen free radicals. | 2001 Dec 5 |
|
| Cr (VI) increases tyrosine phosphorylation through reactive oxygen species-mediated reactions. | 2001 Jun |
|
| In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. | 2001 Mar 1 |
|
| Comparison of the effects of O2*-/HO* free radical- and copper ions-oxidized LDL or lipoprotein(a) on the endothelial cell releases of tissue plasminogen activator and plasminogen activator inhibitor-1. | 2001 Oct 5 |
|
| Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress. | 2003 Dec 19 |
|
| Interactions of growth inhibitory factor with hydroxyl and superoxide radicals. | 2003 Sep |
|
| Role of reactive oxygen species and Cr(VI) in Ras-mediated signal transduction. | 2004 Jan |
|
| OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. | 2005 Feb 18 |
|
| Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells. | 2006 Feb |
|
| Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system. | 2006 Feb 21 |
|
| The story of the discovery of aquaporins: convergent evolution of ideas--but who got there first? | 2006 Oct 30 |
|
| Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions. | 2007 Dec |
|
| Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions. | 2007 Jun 1 |
|
| Gill membrane remodeling with soft-water acclimation in zebrafish (Danio rerio). | 2007 Jun 19 |
|
| Two distinct aquaporin-4 cDNAs isolated from medullary cone of quail kidney. | 2007 May |
|
| A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell. | 2009 Feb |
|
| Tobramycin-induced aquagenic wrinkling of the palms in a patient with cystic fibrosis. | 2009 Jul |
|
| Ferritin enhances salsolinol-mediated DNA strand breakage: protection by carnosine and related compounds. | 2009 Jul 10 |
|
| Evidence for the involvement of aquaporins in sperm motility activation of the teleost gilthead sea bream (Sparus aurata). | 2009 Nov |
|
| Expression and functional characterization of four aquaporin water channels from the European eel (Anguilla anguilla). | 2009 Sep 1 |
|
| Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation. | 2010 Apr 21 |
|
| Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance. | 2010 Aug 1 |
|
| Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. | 2010 Sep 6 |
|
| Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus. | 2011 Apr |
|
| Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase. | 2011 Apr 1 |
|
| Testosterone modulates pituitary vasotocin receptor expression and adrenal activity in osmotically stressed chicken. | 2011 Jan |
|
| Endothelins decrease the expression of aquaporins and plasma membrane water permeability in cultured rat astrocytes. | 2011 Mar |
|
| Water permeability and characterization of aquaporin-11. | 2011 May |
|
| Inhibition of aquaporin-3 water channel in the colon induces diarrhea. | 2012 |
|
| Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation. | 2012 Apr |
|
| Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells. | 2012 Jun |
|
| Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. | 2012 Jun 1 |
|
| A novel aquaporin 3 in killifish (Fundulus heteroclitus) is not an arsenic channel. | 2012 May |
|
| Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD). | 2012 Sep |
|
| Copper(II)-human amylin complex protects pancreatic cells from amylin toxicity. | 2013 Aug 14 |
|
| Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux. | 2013 Feb |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
WHO-ATC |
S01XA03
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
||
|
NCI_THESAURUS |
C68287
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
||
|
NDF-RT |
N0000175811
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
||
|
NCI_THESAURUS |
C597
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
LYR4M0NH37
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY | |||
|
DTXSID8037671
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY | |||
|
17341-25-2
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY | |||
|
923
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY | |||
|
SUB23214
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY | |||
|
C61943
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY | |||
|
29101
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY | |||
|
DB14516
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY | |||
|
100000087148
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY | |||
|
1364429
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY | RxNorm | ||
|
LYR4M0NH37
Created by
admin on Tue Apr 01 20:32:26 GMT 2025 , Edited by admin on Tue Apr 01 20:32:26 GMT 2025
|
PRIMARY |
ACTIVE MOIETY
