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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H32O5
Molecular Weight 376.4865
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of BLXA4

SMILES

CCCCC[C@@H](O)\C=C\C1=C(/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O)C=CC=C1

InChI

InChIKey=HEDVTGFTYROYFE-RREUNBNVSA-N
InChI=1S/C22H32O5/c1-2-3-4-10-19(23)15-13-17-8-5-6-9-18(17)14-16-21(25)20(24)11-7-12-22(26)27/h5-6,8-9,13-16,19-21,23-25H,2-4,7,10-12H2,1H3,(H,26,27)/b15-13+,16-14+/t19-,20+,21-/m1/s1

HIDE SMILES / InChI
Benzo-lipoxin A4 as a bLXA4-ME also known as ClinRinse-1 participated in phase II clinical trials for the treatment of gingival diseases. It was shown that nano-proresolving medicines (NPRM) containing a lipoxin analog (benzo-lipoxin A4, bLXA4) was a mimetic of endogenous resolving mechanisms with potent bioactions. That offered a new therapeutic tissue-engineering approach for the treatment of chronic osteolytic inflammatory diseases.

Approval Year

PubMed

PubMed

TitleDatePubMed
Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.
2011 Sep
Proresolving nanomedicines activate bone regeneration in periodontitis.
2015 Jan
Patents

Sample Use Guides

The topical oral rinse dosage form of BLXA4-ME (also known as ClinRinse-1) will consist of drug substance prepared at a concentration of 1.0 μM in an aqueous vehicle solution
Route of Administration: Dental
Name Type Language
BLXA4
Common Name English
BLXA-4
Code English
7-OCTENOIC ACID, 5,6-DIHYDROXY-8-(2-((1E,3R)-3-HYDROXY-1-OCTEN-1-YL)PHENYL)-, (5S,6R,7E)-
Systematic Name English
BENZO-LIPOXIN A4
Common Name English
BENZO-LXA4
Common Name English
BENZO-LXA-4
Common Name English
7-OCTENOIC ACID, 5,6-DIHYDROXY-8-(2-((1E,3R)-3-HYDROXY-1-OCTENYL)PHENYL)-, (5S,6R,7E)-
Systematic Name English
Code System Code Type Description
CAS
864516-86-9
Created by admin on Sat Dec 16 09:29:35 GMT 2023 , Edited by admin on Sat Dec 16 09:29:35 GMT 2023
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FDA UNII
LXE89WJ787
Created by admin on Sat Dec 16 09:29:35 GMT 2023 , Edited by admin on Sat Dec 16 09:29:35 GMT 2023
PRIMARY
PUBCHEM
58185197
Created by admin on Sat Dec 16 09:29:35 GMT 2023 , Edited by admin on Sat Dec 16 09:29:35 GMT 2023
PRIMARY
DRUG BANK
DB12133
Created by admin on Sat Dec 16 09:29:35 GMT 2023 , Edited by admin on Sat Dec 16 09:29:35 GMT 2023
PRIMARY