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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H21N3O3
Molecular Weight 291.3455
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ESERIDINE

SMILES

[H][C@]12ON(C)CC[C@@]1(C)C3=C(C=CC(OC(=O)NC)=C3)N2C

InChI

InChIKey=CNBHDDBNEKKMJH-ZFWWWQNUSA-N
InChI=1S/C15H21N3O3/c1-15-7-8-17(3)21-13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15-/m0/s1

HIDE SMILES / InChI

Description

Eseridine (Geneserine) has been known for many years as an anticholinergic agent and used in therapy as a gastrointestinal antispastic. Eseridine salicylate is an inhibitor of cholinesterase activity that has been given by mouth in preparations for dyspepsia and other gastric disorders. It has also been studied for the treatment of Alzheimer’s disease.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
100.0 nM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
GENESERINE

PubMed

Sample Use Guides

In Vivo Use Guide
Adult: 30 to 45 drops, 3 times a day, preferably taken 1/2 hour before main meals.
Route of Administration: Oral
In Vitro Use Guide
Geneserine hydrochloride inhibited human Acetylcholinesterase with IC50 value of 100 nM.