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Details

Stereochemistry RACEMIC
Molecular Formula C20H33N2O
Molecular Weight 317.4896
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of HEXOCYCLIUM

SMILES

C[N+]1(C)CCN(CC1)CC(c2ccccc2)(C3CCCCC3)O

InChI

InChIKey=ZRYHPQCHHOKSMD-UHFFFAOYSA-N
InChI=1S/C20H33N2O/c1-22(2)15-13-21(14-16-22)17-20(23,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3,5-6,9-10,19,23H,4,7-8,11-17H2,1-2H3/q+1

HIDE SMILES / InChI
Hexocyclium is an old anticholinergic drug. Hexocyclium is an antimuscarinic. Hexocyclium in therapeutic doses produces a prolonged reduction of gastric acidity. It was used for the treatment of peptic ulcer. Hexocyclium is effective for the control of cramps and diarrhea in cases of irritable bowel syndrome.

Approval Year

Doses

Doses

DosePopulationAdverse events​
100 mg 2 times / day multiple, oral
Highest studied dose
Dose: 100 mg, 2 times / day
Route: oral
Route: multiple
Dose: 100 mg, 2 times / day
Sources: Page: p.18
unhealthy
n = 33
Health Status: unhealthy
Condition: Duodenal ulcer
Population Size: 33
Sources: Page: p.18
PubMed

PubMed

TitleDatePubMed
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
1989 Apr
Patents

Sample Use Guides

Single oral doses of 25 mg and 50 mg
Route of Administration: Oral
In Vitro Use Guide
Acetylcholine-induced concentration-dependent tonic contraction of isolated rat fundus was concentration-dependently antagonized by hexocyclium (KB = 2.82 x 10(-10)M).
Name Type Language
HEXOCYCLIUM
WHO-DD  
Common Name English
4-(.BETA.-CYCLOHEXYL-.BETA.-HYDROXYPHENETHYL)-1,1-DIMETHYLPIPERAZINUM
Common Name English
HEXOCYCLIUM [WHO-DD]
Common Name English
HEXOCYCLIUM CATION
Common Name English
HEXOCYCLIUM ION
Common Name English
Classification Tree Code System Code
WHO-ATC A03AB10
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
WHO-VATC QA03AB10
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
NCI_THESAURUS C29704
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
Code System Code Type Description
DRUG BANK
DB06787
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
PRIMARY
CAS
6004-98-4
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
PRIMARY
PUBCHEM
24199
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
PRIMARY
DRUG CENTRAL
1371
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
PRIMARY
EVMPD
SUB02515MIG
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
PRIMARY
NCI_THESAURUS
C78074
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
PRIMARY
FDA UNII
LL3147PI1T
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
PRIMARY
RXCUI
26867
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
PRIMARY RxNorm
WIKIPEDIA
Hexocyclium
Created by admin on Fri Jun 25 22:33:53 UTC 2021 , Edited by admin on Fri Jun 25 22:33:53 UTC 2021
PRIMARY