HEXOCYCLIUM

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H33N2O
Molecular Weight	317.4888
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

C[N+]1(C)CCN(CC(O)(C2CCCCC2)C3=CC=CC=C3)CC1

InChI

InChIKey=ZRYHPQCHHOKSMD-UHFFFAOYSA-N

InChI=1S/C20H33N2O/c1-22(2)15-13-21(14-16-22)17-20(23,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3,5-6,9-10,19,23H,4,7-8,11-17H2,1-2H3/q+1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13520691 | https://www.ncbi.nlm.nih.gov/pubmed/13487546

Hexocyclium is an old anticholinergic drug. Hexocyclium is an antimuscarinic. Hexocyclium in therapeutic doses produces a prolonged reduction of gastric acidity. It was used for the treatment of peptic ulcer. Hexocyclium is effective for the control of cramps and diarrhea in cases of irritable bowel syndrome.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Muscarinic acetylcholine receptor M1 169 Target ID: CHEMBL276 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2704370 \| https://www.ncbi.nlm.nih.gov/pubmed/9183081 \| https://www.ncbi.nlm.nih.gov/pubmed/8075869	Antagonist 2778	13.0 nM [IC50]
Muscarinic acetylcholine receptor M2 121 Target ID: CHEMBL211 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2704370 \| https://www.ncbi.nlm.nih.gov/pubmed/9183081	Antagonist 2778	40.0 nM [IC50]
Muscarinic acetylcholine receptor M3 159 Target ID: CHEMBL245 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2704370 \| https://www.ncbi.nlm.nih.gov/pubmed/9183081 \| https://www.ncbi.nlm.nih.gov/pubmed/8075869	Antagonist 2778	9.0 nM [IC50]
Muscarinic acetylcholine receptor M4 86 Target ID: CHEMBL1821 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2704370 \| https://www.ncbi.nlm.nih.gov/pubmed/9183081 \| https://www.ncbi.nlm.nih.gov/pubmed/8075869	Antagonist 2778	39.0 nM [IC50]
Muscarinic acetylcholine receptor M5 62 Target ID: CHEMBL2035 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2704370	Antagonist 2778	14.0 nM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Peptic ulcer 72 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13520691 https://www.ncbi.nlm.nih.gov/pubmed/13487546	Primary		Approved 8429	Tral Approved Use Tral is used in the treatment of peptic ulcers. Launch Date 1959

Doses

Dose	Population	Adverse events
100 mg 2 times / day multiple, oral Highest studied dose Dose: 100 mg, 2 times / day Route: oral Route: multiple Dose: 100 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13487546 Page: p.18	unhealthy n = 33 Health Status: unhealthy Condition: Duodenal ulcer Population Size: 33 Sources: https://pubmed.ncbi.nlm.nih.gov/13487546 Page: p.18	Sources: https://pubmed.ncbi.nlm.nih.gov/13487546 Page: p.18

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L2NA2
Alfa Chemistry	189328
Alfa Chemistry	ACM6004984
BOC Sciences	115-63-9
BOC Sciences	6004-98-4
Compound Cloud	101587
Compound Cloud	24199
Frontier Scientific Services	500055010
Frontier Scientific Services	502049006
Frontier Scientific Services	502053275
MuseChem	M069018
NCI Plated 2007	30256
Nanjing Pope Bio-tech	NSTH-C029470
Norris Pharm	NSTH-C029470
NovoSeek	24199
Toronto Research Chemicals	C987483
ZINC	ZINC000000000363	http://zinc15.docking.org/substances/ZINC000000000363
ZINC	ZINC000000897263	http://zinc15.docking.org/substances/ZINC000000897263
eMolecules	261640856
eMolecules	36761515

PubMed

Title	Date	PubMed
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.	1989 Apr	2704370

Patents

Sample Use Guides

In Vivo Use Guide

Single oral doses of 25 mg and 50 mg

Route of Administration: Oral

In Vitro Use Guide

Acetylcholine-induced concentration-dependent tonic contraction of isolated rat fundus was concentration-dependently antagonized by hexocyclium (KB = 2.82 x 10(-10)M).

Name

Type

Language

HEXOCYCLIUM

Common Name

English

4-(.BETA.-CYCLOHEXYL-.BETA.-HYDROXYPHENETHYL)-1,1-DIMETHYLPIPERAZINUM

Common Name

English

Hexocyclium [WHO-DD]

Common Name

English

HEXOCYCLIUM CATION

Common Name

English

HEXOCYCLIUM ION

Common Name

English

Classification Tree Code System Code

WHO-ATC

A03AB10