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Details

Stereochemistry ACHIRAL
Molecular Formula C14H18ClNO4S
Molecular Weight 331.815
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIBRIC ACID

SMILES

C[C@H]1C[C@@H](C)CN(C1)S(=O)(=O)C2=CC(C(O)=O)=C(Cl)C=C2

InChI

InChIKey=IFXSWTIWFGIXQO-AOOOYVTPSA-N
InChI=1S/C14H18ClNO4S/c1-9-5-10(2)8-16(7-9)21(19,20)11-3-4-13(15)12(6-11)14(17)18/h3-4,6,9-10H,5,7-8H2,1-2H3,(H,17,18)/t9-,10+

HIDE SMILES / InChI

Description

Tibric Acid is a sulfamoylbenzoic acid derivative patented by American multinational pharmaceutical corporation Pfizer Inc. as a hypolipidemic agent. In preclinical models, Tibric acid, given orally, was more effective than clofibrate in preventing the hyperlipemic and hypercholesteremic effects of various diets in rats. At high concentrations in vitro, Tibric acid moderately inhibited ADP- or thrombin-induced aggregation of rabbit blood platelets. In patients with severe type IV hyperlipoproteinemia and chylomicronemia, Tibric Acid lowered serum triglyceride and cholesterol values but administration of Tibric Acid to a normal subject did not affect serum lipid levels.

Originator

Approval Year

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
500-​1500 mg​/day
Route of Administration: Oral