Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H18ClNO4S |
Molecular Weight | 331.815 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H]1C[C@@H](C)CN(C1)S(=O)(=O)C2=CC(C(O)=O)=C(Cl)C=C2
InChI
InChIKey=IFXSWTIWFGIXQO-AOOOYVTPSA-N
InChI=1S/C14H18ClNO4S/c1-9-5-10(2)8-16(7-9)21(19,20)11-3-4-13(15)12(6-11)14(17)18/h3-4,6,9-10H,5,7-8H2,1-2H3,(H,17,18)/t9-,10+
Tibric Acid is a sulfamoylbenzoic acid derivative patented by American multinational pharmaceutical corporation Pfizer Inc. as a hypolipidemic agent. In preclinical models, Tibric acid, given orally, was more effective than clofibrate in preventing the hyperlipemic and hypercholesteremic effects of various diets in rats. At high concentrations in vitro, Tibric acid moderately inhibited ADP- or thrombin-induced aggregation of rabbit blood platelets. In patients with severe type IV hyperlipoproteinemia and chylomicronemia, Tibric Acid lowered serum triglyceride and cholesterol values but administration of Tibric Acid to a normal subject did not affect serum lipid levels.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4617230
500-1500 mg/day
Route of Administration:
Oral
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NCI_THESAURUS |
C29703
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C152606
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CHEMBL2104748
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LK312SQ24Z
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253-344-0
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SUB11023MIG
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C067603
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100000082165
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Tibric acid
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ACTIVE MOIETY