ALUMINUM CHLORIDE ANHYDROUS

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	Al.3Cl
Molecular Weight	133.341
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ALUMINUM CHLORIDE ANHYDROUS

Structure Search

SMILES

[Al+3].[Cl-].[Cl-].[Cl-]

InChI

InChIKey=VSCWAEJMTAWNJL-UHFFFAOYSA-K

InChI=1S/Al.3ClH/h;3*1H/q+3;;;/p-3

HIDE SMILES / InChI

Description
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cell membrane 42 Target ID: CHEMBL2364031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22718290 \| https://www.ncbi.nlm.nih.gov/pubmed/10211213	Interacts 323
vasoconstriction 32 Target ID: GO:0042310 Sources: https://www.drugs.com/monograph/aluminum-acetate.html	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 54 Sources: http://www.domeboro.com/about-domeboro/ https://www.drugs.com/monograph/aluminum-acetate.html	Primary		Approved 8429	DOMEBORO Approved Use Temporarily relieves minor skin irritations due to: – Poison ivy \| – Poison oak – Poison sumac \| – Insect bites – Athlete’s foot \| – Rashes caused by soaps, detergents, cosmetics, or jewelry
Otitis 40 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15516810 https://www.ncbi.nlm.nih.gov/pubmed/14724484 https://www.drugs.com/monograph/aluminum-acetate.html	Curative		Approved 8429	DOMEBORO Approved Use This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.

PubMed

Title	Date	PubMed
The ineffectiveness of aluminum subacetate in rheumatoid arthritis.	1948 Apr 8	18911341
Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.	1987 Nov 15	2824607
Cardiovascular manifestations of aluminium phosphide intoxication.	1989 Sep	2632560
Requirement for intramolecular domain interaction in activation of G protein alpha subunit by aluminum fluoride and GDP but not by GTP gamma S.	1994 Nov 25	7961906
Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate.	1995 Nov	8559152
Effect of aluminum phosphide on blood glucose level.	1999 Feb	9949483
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.	1999 May	10327022
Intravascular hemolysis in aluminium phosphide poisoning.	1999 Sep	10496516
Effect of N-acetylcysteine and L-NAME on aluminium phosphide induced cardiovascular toxicity in rats.	2001 Apr	11742581
Cholinesterase inhibition by aluminium phosphide poisoning in rats and effects of atropine and pralidoxime chloride.	2001 Jan	11730559
Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information.	2002	12511178
Aluminum as a toxicant.	2002 Aug	15068131
Bone cell mitogenic action of fluoroaluminate and aluminum fluoride but not that of sodium fluoride involves upregulation of the insulin-like growth factor system.	2002 May	11996908
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.	2003	12851164
Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.	2003 Sep	14552065
Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain.	2003 Sep 15	14507471
Some aspects of astroglial functions and aluminum implications for neurodegeneration.	2006 Aug 30	16529821
Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.	2006 Nov	17119296
Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration.	2006 Nov	17119290
Aluminum and Alzheimer's disease: a new look.	2006 Nov	17119287
The role of aluminum and copper on neuroinflammation and Alzheimer's disease.	2006 Nov	17119285
Ototoxic effect of Burow solution applied to the guinea pig middle ear.	2007 Aug	17450104
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.	2007 Sep-Oct	17870524
Aluminum phosphide fatalities at mild exertion in asymptomatic children: a clue to understand the variations of the autopsy findings.	2009 Aug	19573839
Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area.	2009 May 17	19428954
Blood levels of methemoglobin in patients with aluminum phosphide poisoning and its correlation with patient's outcome.	2011 Mar	21057909
Effect of acute aluminum phosphide exposure on rats: a biochemical and histological correlation.	2012 Nov 23	23041170
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.	2014 Sep	24906048
Molecular basis of carcinogenicity of tungsten alloy particles.	2015 Mar 15	25620057

Patents

Sample Use Guides

In Vivo Use Guide

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use

Route of Administration: Topical

In Vitro Use Guide

Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

Name

Type

Language

ALUMINUM CHLORIDE ANHYDROUS

Common Name

English

ALUMINIUM CHLORIDE ANHYDROUS

Common Name

English

Aluminium chloride [WHO-DD]

Common Name

English

ALUMINUM CHLORIDE [HSDB]

Common Name

English

NSC-143015

Code

English

ALUMINIUM MURIATICUM

Common Name

English

NSC-143016

Code

English

ALUMINUM CHLORIDE [MI]

Common Name

English

ALUMINIUM MURIATICUM [HPUS]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID6029674