Details
Stereochemistry | ACHIRAL |
Molecular Formula | C9H14N6 |
Molecular Weight | 206.2477 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC(=NC(N)=N1)N(CC=C)CC=C
InChI
InChIKey=ROHTVIURAJBDES-UHFFFAOYSA-N
InChI=1S/C9H14N6/c1-3-5-15(6-4-2)9-13-7(10)12-8(11)14-9/h3-4H,1-2,5-6H2,(H4,10,11,12,13,14)
Diallylmelamine was tested in man as a gastric antisecretory agent. In these tests it was inactive. However, when this compound was administered to trained, unanesthetized dogs, it was surprisingly found to have pronounced and prolonged hypotensive activity. Diallylmelamine is an effective hypotensive agent in hypertensive dogs and rats, having a duration of action exceeding twenty-four hours from a single oral dose. It has limited efficacy in normotensive rats. Hypotensive activity of gradual onset is preceded by a latent period of up to two hours and becomes maximal six hours or more after dosing. This agent does not depress cardiac output or sympathetic vasoconstrictor activity.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4222455
Curator's Comment: Rat data
25 mg/kg twice daily for 11 or 12 days
Route of Administration:
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202-096-1
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66682
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4420
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91-77-0
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DTXSID0059031
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LGB76HFI14
Created by
admin on Sat Dec 16 09:51:46 GMT 2023 , Edited by admin on Sat Dec 16 09:51:46 GMT 2023
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SUBSTANCE RECORD