Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H20N2O2 |
| Molecular Weight | 200.278 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)NCCCCCCNC(C)=O
InChI
InChIKey=BNQSTAOJRULKNX-UHFFFAOYSA-N
InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Localization and altered expression of nucleophosmin in the nuclear matrix during the differentiation of human hepatocarcinoma SMMC-7721 cells induced by HMBA. | 2010-12 |
|
| Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake. | 2010-11-15 |
|
| Occupational exposure to HDI: progress and challenges in biomarker analysis. | 2010-10-01 |
|
| Sequential changes in chromatin structure during transcriptional activation in the beta globin LCR and its target gene. | 2010-09 |
|
| HMBA depolymerizes microtubules, activates mitotic checkpoints and induces mitotic block in MCF-7 cells by binding at the colchicine site in tubulin. | 2010-07-01 |
|
| Aberrant expression of nuclear matrix proteins during HMBA-induced differentiation of gastric cancer cells. | 2010-05-07 |
|
| Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies. | 2009-12-04 |
|
| Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting. | 2009-10-29 |
|
| P-TEFb- the final frontier. | 2009-09-02 |
|
| Properties of virion transactivator proteins encoded by primate cytomegaloviruses. | 2009-05-27 |
|
| Gene therapy: the end of the rainbow? | 2009-03-30 |
|
| De novo synthesis of VP16 coordinates the exit from HSV latency in vivo. | 2009-03 |
|
| Hexamethylene bisacetamide can convert nonpermissive human cells to a permissive state for expressing the major immediate-early genes of human cytomegalovirus by up-regulating NF-kappaB activity. | 2009-01-20 |
|
| Control of stochastic gene expression by host factors at the HIV promoter. | 2009-01 |
|
| Discordant varicella-zoster virus glycoprotein C expression and localization between cultured cells and human skin vesicles. | 2008-12-20 |
|
| Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy. | 2008-12 |
|
| Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation. | 2008-11-04 |
|
| [Molecular mechanism underlying differentiation of HL-60 cells induced by hexamethylene bisacetamide]. | 2008-10 |
|
| HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb. | 2008-09-01 |
|
| [Expression and localization of hnRNP A2/B1 during differentiation of human osteosarcoma MG-63 cells induced by HMBA]. | 2008-07 |
|
| PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. | 2008-05-15 |
|
| Hexamethylene bisacetamide as a treatment for T-cell leukemia (T-ALL). | 2008-05 |
|
| Hexamethylene bisacetamide inhibits malignant phenotype in T-ALL cell lines. | 2008-05 |
|
| Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells. | 2008-04-15 |
|
| Non-random subcellular distribution of variant EKLF in erythroid cells. | 2008-04-15 |
|
| Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. | 2008-04-09 |
|
| [Localization of prohibitin in nuclear matrix and its expressive alteration during the differentiation of human osteosarcoma MG-63 cells induced by HMBA]. | 2008-02 |
|
| Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. | 2008-02 |
|
| Effect of hexamethylene bisacetamide (HMBA) on the microtubular system of Tetrahymena pyriformis. | 2008-02 |
|
| Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo. | 2008-01-29 |
|
| Histone modifications associated with herpes simplex virus type 1 genomes during quiescence and following ICP0-mediated de-repression. | 2008-01 |
|
| Relationship between the induction of leukemia cell differentiation and the enhancement of reporter gene expression in 3T3 Swiss cells. | 2008-01 |
|
| PU.1 is dispensable to block erythroid differentiation in Friend erythroleukemia cells. | 2008-01 |
|
| HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription. | 2007-10-12 |
|
| Cellular mRNA activates transcription elongation by displacing 7SK RNA. | 2007-10-10 |
|
| HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy. | 2007-08-01 |
|
| Alteration of nuclear matrix-intermediate filament system and differential expression of nuclear matrix proteins during human hepatocarcinoma cell differentiation. | 2007-05-28 |
|
| Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. | 2007-02 |
|
| Proteomic analysis of erythroid differentiation induced by hexamethylene bisacetamide in murine erythroleukemia cells. | 2007-02 |
|
| Temporal variation in the expression of the p53 protein in proliferating and differentiating murine erythroleukaemia cells. | 2007-01 |
|
| Delayed biosynthesis of varicella-zoster virus glycoprotein C: upregulation by hexamethylene bisacetamide and retinoic acid treatment of infected cells. | 2006-10 |
|
| Enhancement of antitumor activity of herpes simplex virus gamma(1)34.5-deficient mutant for oral squamous cell carcinoma cells by hexamethylene bisacetamide. | 2006-08 |
|
| Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. | 2006-06-05 |
|
| The carbonic anhydrase I locus contains a c-Myb target promoter and modulates differentiation of murine erythroleukemia cells. | 2006-05-04 |
|
| [Changes of nuclear matrix proteins during differentiation of human osteosarcoma MG-63 cells induced by HMBA]. | 2006-04 |
|
| Following the differentiation of human pluripotent stem cells by proteomic identification of biomarkers. | 2006-04 |
|
| Changes of nuclear matrix proteins following the differentiation of human osteosarcoma MG-63 cells. | 2006-02 |
|
| 1,6-Diaminohexane contributes to the hexamethylene bisacetamide-induced erythroid differentiation pathway by stimulating Ca2+ release from inositol 1,4,5-trisphosphate-sensitive stores and promoting Ca2+ influx. | 2006-01-01 |
|
| Differentiation-inducing therapy for solid tumors. | 2006 |
|
| Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb. | 2005-12-21 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C292
Created by
admin on Mon Mar 31 19:38:29 GMT 2025 , Edited by admin on Mon Mar 31 19:38:29 GMT 2025
|
||
|
NCI_THESAURUS |
C1934
Created by
admin on Mon Mar 31 19:38:29 GMT 2025 , Edited by admin on Mon Mar 31 19:38:29 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID2041044
Created by
admin on Mon Mar 31 19:38:29 GMT 2025 , Edited by admin on Mon Mar 31 19:38:29 GMT 2025
|
PRIMARY | |||
|
LA133J59VU
Created by
admin on Mon Mar 31 19:38:29 GMT 2025 , Edited by admin on Mon Mar 31 19:38:29 GMT 2025
|
PRIMARY | |||
|
C014026
Created by
admin on Mon Mar 31 19:38:29 GMT 2025 , Edited by admin on Mon Mar 31 19:38:29 GMT 2025
|
PRIMARY | |||
|
C1125
Created by
admin on Mon Mar 31 19:38:29 GMT 2025 , Edited by admin on Mon Mar 31 19:38:29 GMT 2025
|
PRIMARY | |||
|
3073-59-4
Created by
admin on Mon Mar 31 19:38:29 GMT 2025 , Edited by admin on Mon Mar 31 19:38:29 GMT 2025
|
PRIMARY | |||
|
3616
Created by
admin on Mon Mar 31 19:38:29 GMT 2025 , Edited by admin on Mon Mar 31 19:38:29 GMT 2025
|
PRIMARY | |||
|
95580
Created by
admin on Mon Mar 31 19:38:29 GMT 2025 , Edited by admin on Mon Mar 31 19:38:29 GMT 2025
|
PRIMARY |
SUBSTANCE RECORD
