Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H16ClNO4 |
| Molecular Weight | 357.788 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(C=C1)C(C(=O)C3=CC=C(Cl)C=C3)=C(C)N2CC(O)=O
InChI
InChIKey=DGMZLCLHHVYDIS-UHFFFAOYSA-N
InChI=1S/C19H16ClNO4/c1-11-18(19(24)12-3-5-13(20)6-4-12)15-8-7-14(25-2)9-16(15)21(11)10-17(22)23/h3-9H,10H2,1-2H3,(H,22,23)
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/2940571
https://www.ncbi.nlm.nih.gov/pubmed/6991549
http://www.biomedcentral.com/content/supplementary/s12916-014-0262-7-s2.pdf
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/2940571
https://www.ncbi.nlm.nih.gov/pubmed/6991549
http://www.biomedcentral.com/content/supplementary/s12916-014-0262-7-s2.pdf
The NSAID clometacin is an indometacin derivative. Clometacin is an analgesic drug that binds to human serum albumin (HSA) and inhibits the binding of indomethacin, warfarin, clofibrate and salicylic acid to HSA. Clometacin (DUPERAN) was approved in France in 1977. All preparations containing clometacin were withdrawn in 1987 due to their hepatotoxicity.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Liver damage following clomethacin treatment. 6 cases, including 2 deaths (author's transl)]. | 1981 Sep 19 |
|
| Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies. | 1985 Sep-Oct |
|
| Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems. | 2006 Aug |
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NCI_THESAURUS |
C257
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C017136
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ACTIVE MOIETY
