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Description
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/5334792 | https://www.ncbi.nlm.nih.gov/pubmed/13962902 | DOI: 10.1021/j100700a014

Malethamer is the generic name of a new synthetic hydrocarbon copolymer with extraordinary water-binding properties, being able to absorb 200 times its weight of water. It is physically and chemically binds poliovirus 1 and certain bacterial enterotoxins. Ethylene-maleic anhydride copolymers and their derivatives have come to be considered for a number of applications generally involving the formation of insoluble complexes with proteins and viruses. The copolymer is not absorbed from the gastrointestinal tract and is pharmacologically inert. Malethamer, because of its water absorbing quality, is an effective compound for the symptomatic control of diarrhea, both organic and functional.

Originator

Curator's Comment: # Eli Lilly

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Doses

Doses

DosePopulationAdverse events​
500 mg single, oral
Highest studied dose
Dose: 500 mg
Route: oral
Route: single
Dose: 500 mg
Sources:
unhealthy, CHILD
Health Status: unhealthy
Age Group: CHILD
Sex: M+F
Food Status: UNKNOWN
Sources:
PubMed

PubMed

TitleDatePubMed
The effect of malethamer on the excretion and plasma levels of sodium, potassium, and chloride.
1970-10
Experimental production of diarrhea and its prevention by Malethamer in monkeys.
1967-09
Mechanism study of the action of Malethamer in staphylococcus enterotoxin-induced diarrhea in monkeys.
1967-09
Roentgen study of the comparative effect of malethamer and a placebo on gastrointestinal transit time in diarrheal states.
1967-02
The effect of maleic anhydride ethylene polymer (Malethamer) on intestinal motility.
1966-11
Malethamer in the treatment of children with diarrhea.
1965-12
Patents

Sample Use Guides

500 mg after each bowel movement, but at least four times a day
Route of Administration: Oral
Ammoniated ethylene maleic anhydride copolymers and hydrolysed ethylene maleic anhydride copolymers of molecular weights approximating 120000 completely prevented cytopathogenicity at all Echo 9 virus concentrations (10-2 – 10-5).
Name Type Language
MALETAMER
INN  
INN  
Preferred Name English
MALETHAMER
USAN  
USAN  
Official Name English
21679-CH
Code English
maletamer [INN]
Common Name English
MALETHAMER [USAN]
Common Name English
Code System Code Type Description
NCI_THESAURUS
C175813
Created by admin on Mon Mar 31 21:58:44 GMT 2025 , Edited by admin on Mon Mar 31 21:58:44 GMT 2025
PRIMARY
CAS
67832-40-0
Created by admin on Mon Mar 31 21:58:44 GMT 2025 , Edited by admin on Mon Mar 31 21:58:44 GMT 2025
PRIMARY
FDA UNII
L87FF6DM10
Created by admin on Mon Mar 31 21:58:44 GMT 2025 , Edited by admin on Mon Mar 31 21:58:44 GMT 2025
PRIMARY
ChEMBL
CHEMBL2107933
Created by admin on Mon Mar 31 21:58:44 GMT 2025 , Edited by admin on Mon Mar 31 21:58:44 GMT 2025
PRIMARY
PUBCHEM
6436088
Created by admin on Mon Mar 31 21:58:44 GMT 2025 , Edited by admin on Mon Mar 31 21:58:44 GMT 2025
PRIMARY
SMS_ID
300000025177
Created by admin on Mon Mar 31 21:58:44 GMT 2025 , Edited by admin on Mon Mar 31 21:58:44 GMT 2025
PRIMARY
CAS
29535-27-1
Created by admin on Mon Mar 31 21:58:44 GMT 2025 , Edited by admin on Mon Mar 31 21:58:44 GMT 2025
SUPERSEDED
INN
1713
Created by admin on Mon Mar 31 21:58:44 GMT 2025 , Edited by admin on Mon Mar 31 21:58:44 GMT 2025
PRIMARY
Display Structure of MALETHAMER