Menthyl lactate is derived from menthol, a compound that comes from peppermint oil, or is made synthetically. Menthol has a natural cooling effect, which makes it useful as a topical analgesic to treat skin irritation, pain, itching or sunburn. Despite its cooling benefits, menthol can be a skin irritant. Like menthol, menthyl lactate is cooling, but it causes less skin irritation than menthol. Menthyl lactate also has a refreshing, minty taste. For this reason, some manufacturers use it as a flavoring ingredient. The compound is recommended for use as a flavor in concentrations of 0.005% to 0.2% and in cosmetic and other external products in concentrations ranging from 0.2% to 2.0%. Menthyl lactate is a known compound available e.g. from Haarmann & Reimer GmbH (Germany) under the name FRESCOLAT, Type ML.
CNS Activity
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
| 37.8 µM [IC50] | |||
| 300.0 µM [IC50] | |||
| 30.0 µM [EC50] | |||
| 68.0 µM [IC50] | |||
Cmax
AUC
T1/2
Doses
AEs
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
OverviewOther
| Other Inhibitor | Other Substrate | Other Inducer |
|---|---|---|
Drug as perpetrator
Drug as victim
Tox targets
PubMed
Patents
Sample Use Guides
2.5% of RACEMENTHOL apply to affected area not more than 3 to 4 times daily
Route of Administration:
Topical
After the d-menthol exposure (2.0 g in the 600 ml culture medium), the dry weight of the Microcystis aeruginosa FACHB-905 cells gradually decreased; the decrease in the dry weight after 5d exposure was 29, 12, and 2 mgL(-1) when the initial cell densities were 1.4×10(7), 1.2×10(6), and 2.9×10(5) cellmL(-1), respectively.
ACTIVE MOIETY
(2)