Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C19H27NO |
Molecular Weight | 285.4238 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CCCC[C@]1(CCN(CC3CC3)C2)C4=CC(O)=CC=C4
InChI
InChIKey=KFIQKMINEHFZSM-HKUYNNGSSA-N
InChI=1S/C19H27NO/c21-18-6-3-5-16(12-18)19-9-2-1-4-17(19)14-20(11-10-19)13-15-7-8-15/h3,5-6,12,15,17,21H,1-2,4,7-11,13-14H2/t17-,19-/m0/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/2831363
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2831363
Ciprefadol is an opioid analgesic drug. It binds with a high affinity to mu (Ki 4.2 nM) and kappa (Ki 2.5 nM) opioid receptors. In vivo, ciprefadol displays mixed antagonist/agonist activity in the mouse writhing and the rat tail heat tests: in low doses, the compound inhibits the analgesic effect of morphine, while at higher doses it displays analgesic effect. Chronic administration of ciprefadol to rhesus monkeys produced a marked physical dependence more severe than that of morphine, and its effect was consistent with what would be expected of a potent, long-lasting morphine-like agonist.
Approval Year
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NCI_THESAURUS |
C241
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SUB07467MIG
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4454
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CHEMBL2111073
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100000081539
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Ciprefadol
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59889-36-0
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C79933
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DTXSID00208605
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L6RFK0CJ8K
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333483
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)