ACETYL HEXAPEPTIDE-8 (ARGIRELINE®), a hexapeptide Ac-EEMQRR-NH2, is an anti-wrinkling agent. It significantly inhibits neurotransmitter release with a potency similar to that of botulinum toxin. ACETYL HEXAPEPTIDE-8 (ARGIRELINE®) is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation. If the SNARE complex is slightly destabilized, the vesicle can not release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The study of cellular cytotoxicity of argireline - an anti-aging peptide. | 2014 |
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| The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. | 2013-04 |
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| Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy. | 2013-03 |
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| Preparation and stability of cosmetic formulations with an anti-aging peptide. | 2006-11-21 |
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| A synthetic hexapeptide (Argireline) with antiwrinkle activity. | 2002-10 |
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