Acetyl Hexapeptide-8 Amide

Possibly Marketed Outside US

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18498523 | https://wrinklesystem.com/laboratorydata/argireline.pdf

ACETYL HEXAPEPTIDE-8 (ARGIRELINE®), a hexapeptide Ac-EEMQRR-NH2, is an anti-wrinkling agent. It significantly inhibits neurotransmitter release with a potency similar to that of botulinum toxin. ACETYL HEXAPEPTIDE-8 (ARGIRELINE®) is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation. If the SNARE complex is slightly destabilized, the vesicle can not release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.

Originator

Approval Year

PubMed

Title	Date	PubMed
A synthetic hexapeptide (Argireline) with antiwrinkle activity.	2002 Oct	18498523
The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.	2013 Apr	23417317
The study of cellular cytotoxicity of argireline - an anti-aging peptide.	2014	24644551

Name

Type

Language

Acetyl Hexapeptide-8

Preferred Name

English

Acetyl Hexapeptide-8 Amide

Official Name

English

L-Argininamide, N-acetyl-L-α-glutamyl-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-

Systematic Name

English

ARGIRELINE

Common Name

English

Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2

Systematic Name

English

ACETYL HEXAPEPTIDE-8 [INCI]

Common Name

English

Acetyl hexapeptide-3 [WHO-DD]

Common Name

English

N-Acetyl-L-α-glutamyl-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide

Systematic Name

English

Code System Code Type Description

CAS

616204-22-9