SIMFIBRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H26Cl2O6
Molecular Weight	469.355
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(OC1=CC=C(Cl)C=C1)C(=O)OCCCOC(=O)C(C)(C)OC2=CC=C(Cl)C=C2

InChI

InChIKey=JLRNKCZRCMIVKA-UHFFFAOYSA-N

InChI=1S/C23H26Cl2O6/c1-22(2,30-18-10-6-16(24)7-11-18)20(26)28-14-5-15-29-21(27)23(3,4)31-19-12-8-17(25)9-13-19/h6-13H,5,14-15H2,1-4H3

HIDE SMILES / InChI

Description
Sources: http://www.genome.jp/dbget-bin/www_bget?D01212
Curator's Comment: Description was created based on several sources, including http://link.springer.com.sci-hub.cc/article/10.1007/BF03286654

Simfibrate, a derivative of clofibrate, is a hypolipidemic drug, that lowers serum chlolesterol and triglycerids. Under the brand name Cholesolvin it is indicated for hyperlipidaemia associated with arteriosclerosis, cerebral atherosclerosis, coronary arteriosclerosis, hypertension, diabetes.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Triglyceride Biosynthesis 1 Target ID: WP266 Sources: http://www.genome.jp/dbget-bin/www_bget?D01212	Inhibitor 8297
Platelet activation, signaling and aggregation 1 Target ID: WP3481 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6417824	Inhibitor 8297
Cholesterol Biosynthesis 2 Target ID: WP197 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6417824	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hyperlipidemia 80 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6417824	Primary		Approved 8429	Cholesolvin Approved Use Indications: hyperlipidaemia associated with arteriosclerosis, cerebral atherosclerosis, coronary arteriosclerosis, hypertension, diabetes.

PubMed

Title	Date	PubMed
Response to: Laparoscopic cholecystectomy is safe and effective for the treatment of biliary dyskinesia in the pediatric population.	2010 Dec	21265362

Patents

Sample Use Guides

In Vivo Use Guide

1.5 g/day P.O

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

SIMFIBRATE

Official Name

English

SIMFIBRATE [MI]

Common Name

English

CLY-503

Code

English

Simfibrate [WHO-DD]

Common Name

English

simfibrate [INN]

Common Name

English

SIMFIBRATE [JAN]

Common Name

English

CHOLESOLVIN

Brand Name

English

SIMFIBRATE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

C10AB06