Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H20ClF3N2O.ClH |
| Molecular Weight | 433.295 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.FC(F)(F)C1=C(Cl)C(=CC=C1)C(=O)N[C@H]([C@@H]2CCCCN2)C3=CC=CC=C3
InChI
InChIKey=YGCZZYKACZXKHK-AKXYIILFSA-N
InChI=1S/C20H20ClF3N2O.ClH/c21-17-14(9-6-10-15(17)20(22,23)24)19(27)26-18(13-7-2-1-3-8-13)16-11-4-5-12-25-16;/h1-3,6-10,16,18,25H,4-5,11-12H2,(H,26,27);1H/t16-,18-;/m0./s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Targeting Glycine Reuptake in Alcohol Seeking and Relapse. | 2018-04 |
|
| Discovery of 3-Chloro-N-{(S)-[3-(1-ethyl-1H-pyrazol-4-yl)phenyl][(2S)-piperidine-2-yl]methyl}-4-(trifluoromethyl)pyridine-2-carboxamide as a Potent Glycine Transporter 1 Inhibitor. | 2016 |
|
| Involvement of the strychnine-sensitive glycine receptor in the anxiolytic effects of GlyT1 inhibitors on maternal separation-induced ultrasonic vocalization in rat pups. | 2015-01-05 |
|
| SSR504734 enhances basal expression of prepulse inhibition but exacerbates the disruption of prepulse inhibition by apomorphine. | 2013-11 |
|
| Inhibition of glycine transporter-1 reduces cue-induced nicotine-seeking, but does not promote extinction of conditioned nicotine cue responding in the rat. | 2013-09 |
|
| Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1. | 2012-07-09 |
|
| Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. | 2012-06-28 |
|
| Prepulse inhibition of the startle reflex and response to antipsychotic treatments in two outbred mouse strains in comparison to the inbred DBA/2 mouse. | 2011-06 |
|
| In vivo evaluation of carbon-11-labelled non-sarcosine-based glycine transporter 1 inhibitors in mice and conscious monkeys. | 2011-05 |
|
| Amino-terminal isoforms of the human glycine transporter GlyT1 exhibit similar pharmacology. | 2011-02-16 |
|
| Pharmacological characterization of [³H]CHIBA-3007 binding to glycine transporter 1 in the rat brain. | 2011 |
|
| Blockade of glycine transporter 1 by SSR-504734 promotes cognitive flexibility in glycine/NMDA receptor-dependent manner. | 2010-11-23 |
|
| SSR504734, a glycine transporter-1 inhibitor, attenuates acquisition and expression of contextual conditioned fear in rats. | 2010-09 |
|
| Interactions between the glycine transporter 1(GlyT1) inhibitor SSR504734 and psychoactive drugs in mouse motor behaviour. | 2009-08 |
Patents
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|---|---|---|---|---|
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Common Name | English | ||
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Preferred Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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615571-23-8
Created by
admin on Tue Apr 01 16:46:53 GMT 2025 , Edited by admin on Tue Apr 01 16:46:53 GMT 2025
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9954539
Created by
admin on Tue Apr 01 16:46:53 GMT 2025 , Edited by admin on Tue Apr 01 16:46:53 GMT 2025
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L297UZF32G
Created by
admin on Tue Apr 01 16:46:53 GMT 2025 , Edited by admin on Tue Apr 01 16:46:53 GMT 2025
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PRIMARY | |||
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300000042454
Created by
admin on Tue Apr 01 16:46:53 GMT 2025 , Edited by admin on Tue Apr 01 16:46:53 GMT 2025
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
