R-130823

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H26FN3
Molecular Weight	423.5245
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C2=C(C(=CN2)C3=CCN(CCC4=CC=CC=C4)CC3)C5=CC=NC=C5

InChI

InChIKey=XLEONXLSQBBRAN-UHFFFAOYSA-N

InChI=1S/C28H26FN3/c29-25-8-6-24(7-9-25)28-27(23-10-15-30-16-11-23)26(20-31-28)22-13-18-32(19-14-22)17-12-21-4-2-1-3-5-21/h1-11,13,15-16,20,31H,12,14,17-19H2

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Novel p38 mitogen-activated protein kinase inhibitor R-130823 protects cartilage by down-regulating matrix metalloproteinase-1,-13 and prostaglandin E2 production in human chondrocytes.	2006-02	16399619
Novel p38 MAP kinase inhibitor R-130823 suppresses IL-6, IL-8 and MMP-13 production in spheroid culture of human synovial sarcoma cell line SW 982.	2005-10-15	15888346
R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models.	2005-01-04	15627439

Patents

Name

Type

Language

2-(4-FLUOROPHENYL)-4-(1-PHENETHYL-1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-3-(PYRIDIN-4-YL)-1H-PYRROLE

Preferred Name

English

R-130823

Common Name

English

PYRIDINE, 4-(5-(4-FLUOROPHENYL)-4-(4-PYRIDINYL)-1H-PYRROL-3-YL)-1,2,3,6-TETRAHYDRO-1-(2-PHENYLETHYL)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

9910199

Created by admin on Mon Mar 31 22:31:14 GMT 2025 , Edited by admin on Mon Mar 31 22:31:14 GMT 2025

PRIMARY

FDA UNII

L2387U4N8Y

Created by admin on Mon Mar 31 22:31:14 GMT 2025 , Edited by admin on Mon Mar 31 22:31:14 GMT 2025

PRIMARY

CAS

321344-32-5

Created by admin on Mon Mar 31 22:31:14 GMT 2025 , Edited by admin on Mon Mar 31 22:31:14 GMT 2025

PRIMARY

ACTIVE MOIETY


					L2387U4N8Y

R-130823