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Details

Stereochemistry ACHIRAL
Molecular Formula C9H12N4O3
Molecular Weight 224.2166
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETOFYLLINE

SMILES

CN1C2=C(N(CCO)C=N2)C(=O)N(C)C1=O

InChI

InChIKey=NWPRCRWQMGIBOT-UHFFFAOYSA-N
InChI=1S/C9H12N4O3/c1-11-7-6(8(15)12(2)9(11)16)13(3-4-14)5-10-7/h5,14H,3-4H2,1-2H3

HIDE SMILES / InChI

Description

Etofylline [7-(2-hydroxyethyl)theophylline] is a N-7-substituted derivative of theophylline, a smooth muscle relaxant. Etofylline is used to relieve bronchoconstriction. It may act as a phosphodiesterase inhibitor and adenosine receptor antagonist.

CNS Activity

PMID

PMID

TitleDatePMID
Determination of theophylline by HPLC and GC-IDMS, the effect of chemically similar xanthine derivatives on the specificity of the method and the possibility of paracetamol as interfering substance.
2002
The effects of intravenously administered methylxanthine preparations on the glycoconjugate composition of goblet cells in rabbit tracheal epithelium.
2002
Method development for determining the antibacterial linezolid in human serum by micellar electrokinetic capillary chromatography.
2002 Nov 7
The effects of intravenously administered methylxanthines on the proportion of goblet cells containing fucosylated glycoconjugates in rabbit tracheal epithelium.
2004 Feb
Investigation of the aqueous dissolution of semicrystalline poly(ethylene oxide) using infrared chemical imaging: the effects of molecular weight and crystallinity.
2005 Aug
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
A simple and rapid HPLC/UV method for the simultaneous quantification of theophylline and etofylline in human plasma.
2007 Apr 1
Simultaneous determination of salbutamol sulphate, bromhexine hydrochloride and etofylline in pharmaceutical formulations with the use of four rapid derivative spectrophotometric methods.
2007 Jul 30
Simultaneous determination of multi drug components Theophylline, Etofylline, Guaiphenesine and Ambroxol Hydrochloride by validated RP-HPLC method in liquid dosage form.
2008 Apr
Surface-imprinted nanostructured layer-by-layer film for molecular recognition of theophylline derivatives.
2008 Oct 21
A liquid chromatography method for quantifying caffeine dissolution from pharmaceutical formulations into colloidal, fat-rich media.
2010 Jul 1
Patent

Patent

Sample Use Guides

In Vivo Use Guide
up to 1.5 g/day
Route of Administration: oral, intravenous
Name Type Language
ETOFYLLINE
EP   INN   MART.   MI   WHO-DD  
INN  
Official Name English
7-(2-HYDROXYETHYL)THEOPHYLLINE
Systematic Name English
ETOFYLLINE [MI]
Common Name English
FREKAPHYLLIN
Common Name English
KT-200G
Code English
THEOPHYLLINE RELATED COMPOUND F
USP-RS  
Common Name English
NSC-113373
Code English
SOLUPHYLLINE
Common Name English
THEOPHYLLINE RELATED COMPOUND F [USP-RS]
Common Name English
THEOPHYLLINE IMPURITY F [EP]
Common Name English
PHYLLOCORMIN N
Common Name English
OXYPHYLLIN
Brand Name English
ETOFYLLINE [MART.]
Common Name English
ETOFYLLINE [EP]
Common Name English
7-(2-HYDROXYETHYL)-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE
Systematic Name English
ETOFYLLINE [WHO-DD]
Common Name English
ETOFYLLINE [INN]
Common Name English
Code System Code Type Description
PUBCHEM
1892
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY SWITZERF
MERCK INDEX
M5194
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY Merck Index
CAS
519-37-9
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY
MESH
C008749
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY
INN
1667
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY
ChEMBL
CHEMBL699
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY
ECHA (EC/EINECS)
208-269-8
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY
EVMPD
SUB07324MIG
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY
EPA CompTox
519-37-9
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY
RXCUI
24611
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY RxNorm
NCI_THESAURUS
C80611
Created by admin on Tue Mar 06 12:00:07 UTC 2018 , Edited by admin on Tue Mar 06 12:00:07 UTC 2018
PRIMARY