U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ABSOLUTE
Molecular Formula C26H30O8
Molecular Weight 470.5116
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LIMONIN

SMILES

CC1(C)O[C@H]2CC(=O)OC[C@@]23[C@H]1CC(=O)[C@]4(C)[C@@H]3CC[C@@]5(C)[C@@H](OC(=O)[C@H]6O[C@@]456)C7=COC=C7

InChI

InChIKey=KBDSLGBFQAGHBE-MSGMIQHVSA-N
InChI=1S/C26H30O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-15,17,19-20H,5,7,9-10,12H2,1-4H3/t14-,15-,17-,19-,20+,23-,24-,25+,26+/m0/s1

HIDE SMILES / InChI

Description

Limonin is a limonoid, and a bitter, white, crystalline substance found in citrus and other plants. In vitro experiments shows that limonin possess anti-HIV-1, and anti-cancer properties.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Viability of SW480 colon cancer cells after treatment with limonoids was measured by the MTT method. Approximately 10*10^3 cells/well were plated into a 96-well. After 24 h of growth, media was replaced along with compounds at concentrations ranging from 6.25 to 100 uM. After 24, 48, and 72 h, MTT solutionwas added to each well and incubated at 37 C for 2 h.