FUREGRELATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H11NO3
Molecular Weight	253.2527
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1=CC2=C(O1)C=CC(CC3=CC=CN=C3)=C2

InChI

InChIKey=VHWFITPGPFLBGT-UHFFFAOYSA-N

InChI=1S/C15H11NO3/c17-15(18)14-8-12-7-10(3-4-13(12)19-14)6-11-2-1-5-16-9-11/h1-5,7-9H,6H2,(H,17,18)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6086857 | https://www.ncbi.nlm.nih.gov/pubmed/2717519

Furegrelate (previously known as U-63557A), a selective orally active thromboxane synthase inhibitor, with potential for the treatment of various diseases including hypertension, thrombosis, and renal disorders, arrhythmias, but these studies were discontinued.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Thromboxane-A synthase 21 Target ID: P24557\|\|\|Q8IUN1\|\|\|Q9HD82 Gene ID: 6916.0 Gene Symbol: TBXAS1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/6685888	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Pulmonary arterial hypertension 35 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22837860	Primary	Not Provided 504	Unknown Approved Use Unknown
Arrhythmia 38 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2159727	Primary	Not Provided 504	Unknown Approved Use Unknown
Thrombosis 22 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3183064	Primary	Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate.	1983 Aug	6316421

Sample Use Guides

In Vivo Use Guide

The absorption and disposition of the parent drug in normal male volunteers have been studied after single- and multiple-dose oral administration. The results from the single-dose study indicate that furegrelate is rapidly absorbed, with a Tmax of 1.0-1.7 hr, has an apparent terminal disposition rate constant of 0.12-0.17 hr-1, and is eliminated primarily by the kidney, with 62-78% of the dose excreted as parent drug

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

FUREGRELATE

Official Name

English

furegrelate [INN]

Common Name

English

5-(3-PYRIDYLMETHYL)-2-BENZOFURANCARBOXYLATE

Systematic Name

English

2-BENZOFURANCARBOXYLIC ACID, 5-(3-PYRIDINYLMETHYL)-

Common Name

English

5-(3-PYRIDYLMETHYL)-2-BENZOFURANCARBOXYLIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C471