PRATOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12O4
Molecular Weight	268.2641
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C=C3

InChI

InChIKey=SQVXWIUVAILQRH-UHFFFAOYSA-N

InChI=1S/C16H12O4/c1-19-12-5-2-10(3-6-12)15-9-14(18)13-7-4-11(17)8-16(13)20-15/h2-9,17H,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29019920 | http://onlinelibrary.wiley.com/doi/10.1002/ptr.2650050104/full | https://www.ncbi.nlm.nih.gov/pubmed/16707255

Pratol is an O-methylated flavone that can be found in Trifolium pratense and Caragana microphylla. It has been found to induce melanogenesis and stimulate tyrosinase activity in melanoma cells and may have potential as a tanning agent in the cosmetics industry. Pratol has also been investigated for potential anti-ischemic effects.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Ischemia 16 Sources: http://onlinelibrary.wiley.com/doi/10.1002/ptr.2650050104/full	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.	1994 Aug 3	7520698
Inhibitory activity of flavonoids and tannins against HIV-1 protease.	2000 Sep	10993207
Antinociceptive activity and chemical composition of constituents from Caragana microphylla seeds.	2007 Feb	16707255

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

PRATOL

Common Name

English

NSC-123414

Code

English

7-HYDROXY-4-METHOXYFLAVONE

Common Name

English

7-HYDROXY-2-(4-METHOXYPHENYL)CHROMEN-4-ONE

Systematic Name

English

Code System Code Type Description

CAS

487-24-1