NORMETHADONE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H25NO
Molecular Weight	295.4186
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of NORMETHADONE

Structure Search

SMILES

CCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=WCJFBSYALHQBSK-UHFFFAOYSA-N

InChI=1S/C20H25NO/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14H,4,15-16H2,1-3H3

HIDE SMILES / InChI

Description
Sources: http://www.rexall.ca/articles/view/1486/Cophylac

Normethadone is a derivate of opioid analgetic methadone, used as component of antitussive drops in Canada. Illicit drug.

CNS Activity

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Mu-type opioid receptor 61 Target ID: P33535\|\|\|Q64064 Gene ID: 25601.0 Gene Symbol: Oprm1 Target Organism: Rattus norvegicus (Rat) Sources: http://www.ncbi.nlm.nih.gov/pubmed/7602488	Agonist 2678

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: http://www.rexall.ca/articles/view/1486/Cophylac	Primary		Approved 8429	Cophylac Approved Use Cough

PubMed

PubMed

Title	Date	PubMed
Phenyl-substituted normethadones: synthesis and pharmacology.	1995 Mar	7602488
Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry.	2009 Apr 15	19232849

Sample Use Guides

In Vivo Use Guide

Cophylac (normethadone HCl 10 mg and p-hydroxyephedrine HCl 20 mg): 15 drops twice daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

NORMETHADONE

Official Name

English

1,1-DIPHENYL-1-(2-DIMETHYLAMINOETHYL)-2-BUTANONE

Systematic Name

English

NORMETHADONE [MI]

Common Name

English

normethadone [INN]

Common Name

English

6-DIMETHYLAMINO-4,4-DIPHENYL-3-HEXANONE

Systematic Name

English

HOECHST-10582

Code

English

MEPIDON

Common Name

English

ISOMETHADONE I

Common Name

English

HOECHST 10582

Code

English

IDS-NN-007

Code

English

J5.915C

Code

English

NSC-19598

Code

English

Normethadone [WHO-DD]

Common Name

English

EUCOPON

Common Name

English

Classification Tree Code System Code

DEA NO.

9635

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WHO-ATC

R05DA06

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NCI_THESAURUS

C67413

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WHO-VATC

QR05DA06

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Code System Code Type Description

RXCUI

32009

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RxNorm

EPA CompTox

DTXSID6057748

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NCI_THESAURUS

C76843

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WIKIPEDIA

NORMETHADONE

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Normethadone (INN, BAN; brand names Cophylac, Dacartil, Eucopon, Mepidon, Noramidone, Normedon, and others), also known as desmethylmethadone or phenyldimazone, is a synthetic opioid analgesic and antitussive agent.Normethadone is listed under the Single Convention on Narcotic Drugs 1961 and is an Schedule I Narcotic controlled substance in the United States, with a DEA ACSCN of 9635 and an annual manufacturing quota of 2 grams.

DRUG CENTRAL

1969

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FDA UNII

KR2L2A68XL

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NSC

19598

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INN

467

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ECHA (EC/EINECS)

207-401-1

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EVMPD

SUB09376MIG

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MERCK INDEX

m8068

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Merck Index

CAS

467-85-6

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SMS_ID

100000083620

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PUBCHEM

10090

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DRUG BANK

DB11609

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MESH

C005845

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ChEMBL

CHEMBL346331

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ACTIVE MOIETY


					KR2L2A68XL

PARENT (SALT/SOLVATE)


					3R57N9908J

NORMETHADONE OXALATE

PARENT (SALT/SOLVATE)


					OIV53II16G

NORMETHADONE HYDROCHLORIDE

PARENT (SALT/SOLVATE)


					06USP7T2XG

NORMETHADONE HYDROBROMIDE

SALT/SOLVATE (PARENT)


					632S02T2CC

NORMETHADONE PICRATE