Details
Stereochemistry | ACHIRAL |
Molecular Formula | C20H25NO |
Molecular Weight | 295.4186 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
InChI
InChIKey=WCJFBSYALHQBSK-UHFFFAOYSA-N
InChI=1S/C20H25NO/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14H,4,15-16H2,1-3H3
DescriptionSources: http://www.rexall.ca/articles/view/1486/Cophylac
Sources: http://www.rexall.ca/articles/view/1486/Cophylac
Normethadone is a derivate of opioid analgetic methadone, used as component of antitussive drops in Canada. Illicit drug.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P33535|||Q64064 Gene ID: 25601.0 Gene Symbol: Oprm1 Target Organism: Rattus norvegicus (Rat) Sources: http://www.ncbi.nlm.nih.gov/pubmed/7602488 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Cophylac Approved UseCough |
Doses
Dose | Population | Adverse events |
---|---|---|
100 mg single, oral Overdose |
healthy, CHILD Health Status: healthy Age Group: CHILD Sex: M Food Status: UNKNOWN Sources: |
Disc. AE: Hyporeflexia, Coma... AEs leading to discontinuation/dose reduction: Hyporeflexia Sources: Coma Fever Disseminated intravascular coagulation Hepatocellular injury Renal failure (grade 1) |
15 drop 2 times / day multiple, oral Recommended Dose: 15 drop, 2 times / day Route: oral Route: multiple Dose: 15 drop, 2 times / day Sources: |
unhealthy, CHILD|ADOLESCENT|ADULT Health Status: unhealthy Age Group: CHILD|ADOLESCENT|ADULT Sex: M+F Food Status: UNKNOWN Sources: |
Disc. AE: Opioid abuse, Opioid type dependence... AEs leading to discontinuation/dose reduction: Opioid abuse Sources: Opioid type dependence Respiratory depression (grade 3-5) Neonatal opioid withdrawal syndrome (grade 4) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Coma | Disc. AE | 100 mg single, oral Overdose |
healthy, CHILD Health Status: healthy Age Group: CHILD Sex: M Food Status: UNKNOWN Sources: |
Disseminated intravascular coagulation | Disc. AE | 100 mg single, oral Overdose |
healthy, CHILD Health Status: healthy Age Group: CHILD Sex: M Food Status: UNKNOWN Sources: |
Fever | Disc. AE | 100 mg single, oral Overdose |
healthy, CHILD Health Status: healthy Age Group: CHILD Sex: M Food Status: UNKNOWN Sources: |
Hepatocellular injury | Disc. AE | 100 mg single, oral Overdose |
healthy, CHILD Health Status: healthy Age Group: CHILD Sex: M Food Status: UNKNOWN Sources: |
Hyporeflexia | Disc. AE | 100 mg single, oral Overdose |
healthy, CHILD Health Status: healthy Age Group: CHILD Sex: M Food Status: UNKNOWN Sources: |
Renal failure | grade 1 Disc. AE |
100 mg single, oral Overdose |
healthy, CHILD Health Status: healthy Age Group: CHILD Sex: M Food Status: UNKNOWN Sources: |
Opioid abuse | Disc. AE | 15 drop 2 times / day multiple, oral Recommended Dose: 15 drop, 2 times / day Route: oral Route: multiple Dose: 15 drop, 2 times / day Sources: |
unhealthy, CHILD|ADOLESCENT|ADULT Health Status: unhealthy Age Group: CHILD|ADOLESCENT|ADULT Sex: M+F Food Status: UNKNOWN Sources: |
Opioid type dependence | Disc. AE | 15 drop 2 times / day multiple, oral Recommended Dose: 15 drop, 2 times / day Route: oral Route: multiple Dose: 15 drop, 2 times / day Sources: |
unhealthy, CHILD|ADOLESCENT|ADULT Health Status: unhealthy Age Group: CHILD|ADOLESCENT|ADULT Sex: M+F Food Status: UNKNOWN Sources: |
Respiratory depression | grade 3-5 Disc. AE |
15 drop 2 times / day multiple, oral Recommended Dose: 15 drop, 2 times / day Route: oral Route: multiple Dose: 15 drop, 2 times / day Sources: |
unhealthy, CHILD|ADOLESCENT|ADULT Health Status: unhealthy Age Group: CHILD|ADOLESCENT|ADULT Sex: M+F Food Status: UNKNOWN Sources: |
Neonatal opioid withdrawal syndrome | grade 4 Disc. AE |
15 drop 2 times / day multiple, oral Recommended Dose: 15 drop, 2 times / day Route: oral Route: multiple Dose: 15 drop, 2 times / day Sources: |
unhealthy, CHILD|ADOLESCENT|ADULT Health Status: unhealthy Age Group: CHILD|ADOLESCENT|ADULT Sex: M+F Food Status: UNKNOWN Sources: |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.rexall.ca/articles/view/1486/Cophylac
Cophylac (normethadone HCl 10 mg and p-hydroxyephedrine HCl 20 mg): 15 drops twice daily
Route of Administration:
Oral
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Classification Tree | Code System | Code | ||
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DEA NO. |
9635
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WHO-ATC |
R05DA06
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NCI_THESAURUS |
C67413
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WHO-VATC |
QR05DA06
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32009
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PRIMARY | RxNorm | ||
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DTXSID6057748
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C76843
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NORMETHADONE
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PRIMARY | Normethadone (INN, BAN; brand names Cophylac, Dacartil, Eucopon, Mepidon, Noramidone, Normedon, and others), also known as desmethylmethadone or phenyldimazone, is a synthetic opioid analgesic and antitussive agent.Normethadone is listed under the Single Convention on Narcotic Drugs 1961 and is an Schedule I Narcotic controlled substance in the United States, with a DEA ACSCN of 9635 and an annual manufacturing quota of 2 grams. | ||
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1969
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KR2L2A68XL
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19598
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467
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207-401-1
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SUB09376MIG
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m8068
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467-85-6
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100000083620
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10090
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DB11609
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C005845
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CHEMBL346331
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ACTIVE MOIETY
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