Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H8O2 |
| Molecular Weight | 160.1693 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=COC2=C(C=CC=C2)C1=O
InChI
InChIKey=ABJKIHHNDMEBNA-UHFFFAOYSA-N
InChI=1S/C10H8O2/c1-7-6-12-9-5-3-2-4-8(9)10(7)11/h2-6H,1H3
Methylchromone (3-methylchromone) is the first synthetic chromone to be used clinically. It has both antispasmodic and coronary vasodilator actions. It was recommended for the treatment of angina pectoris but it doesn’t produce any remarkable improvements and its clinical use has been discontinued. Osteomalacia case caused by the ingestion of 3-methylchromone was reported. 3-methylchromone was used in ureteral lithiasis and gravels. 3-methylchromone stated to have better vitamin K activity.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Trial use of 3-methyl-chromone as a fundamental treatment of angina pectoris]. | 1954 Jun 2 |
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| [Prevention & treatment of anginose attacks of coronary origin with 3-methylchromone]. | 1957 Aug |
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| [The preparation for surgery of patients with choledochal lithiasis; combined use of 3-methylchromone and theophylline]. | 1959 Aug 15-22 |
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| [Clinical experimentation with 3-methylchromone (chromethyl) in some urological forms]. | 1959 Nov-Dec |
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| [Characteristic reactions and the determination of 3-methylchromone]. | 1961 Jan |
Patents
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29698
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C66121
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m11093
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CHEMBL2105215
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SUB08864MIG
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ACTIVE MOIETY
