Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C15H13ClO4 |
| Molecular Weight | 292.714 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(OC1=CC=C(OC2=CC=C(Cl)C=C2)C=C1)C(O)=O
InChI
InChIKey=BSFAVVHPEZCASB-UHFFFAOYSA-N
InChI=1S/C15H13ClO4/c1-10(15(17)18)19-12-6-8-14(9-7-12)20-13-4-2-11(16)3-5-13/h2-10H,1H3,(H,17,18)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cancer biomarker AKR1B10 and carbonyl metabolism. | 2009-03-16 |
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| Bezafibrate prevents hepatic stellate cell activation and fibrogenesis in a murine steatohepatitis model, and suppresses fibrogenic response induced by transforming growth factor-beta1 in a cultured stellate cell line. | 2008-10 |
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| Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers. | 2008-04-28 |
|
| PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes. | 2007-06 |
|
| Activating effect of benzbromarone, a uricosuric drug, on peroxisome proliferator-activated receptors. | 2007 |
|
| Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms. | 2006-04 |
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| Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. | 2005-10-03 |
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| Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. | 2005-09-02 |
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| Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport. | 2005-07 |
|
| Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes. | 2005-01 |
|
| A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice. | 2004-06 |
|
| Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB. | 2002-01-11 |
|
| Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells. | 1999-06 |
|
| Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha. | 1998-12 |
|
| Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids. | 1995-08-15 |
Patents
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KIH4IO8Q8Z
Created by
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26129-32-8
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DTXSID90949015
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326777
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64928
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clofop
Created by
admin on Mon Mar 31 18:23:47 GMT 2025 , Edited by admin on Mon Mar 31 18:23:47 GMT 2025
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SUBSTANCE RECORD
