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Details

Stereochemistry RACEMIC
Molecular Formula C11H8ClNO2
Molecular Weight 221.64
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYPROXIMIDE

SMILES

[H][C@]12C[C@]1(C(=O)NC2=O)C3=CC=C(Cl)C=C3

InChI

InChIKey=YYGANUVABKDFDW-KCJUWKMLSA-N
InChI=1S/C11H8ClNO2/c12-7-3-1-6(2-4-7)11-5-8(11)9(14)13-10(11)15/h1-4,8H,5H2,(H,13,14,15)/t8-,11+/m1/s1

HIDE SMILES / InChI
Cyproximide is a psychoactive drug discovered by American Cyanamid company. The drug exhibited activity as a central nervous system depressant and was claimed to be useful as a tranquilizing agent, hypnotic agent or muscle relaxant. The phenobarbital-like activity of cyproximide after intraperitoneal administration was demonstrated in rod traversal, clinging and righting reflex tests in mice. In addition to CNS depressant activity, cyproximide had a mild stimulant and antidepressant effects, which were shown by the restoration of exploratory behavior and an increase in locomotor activity in mice. Chronic administration of the drug led to a greater incidence of proliferative lesions in the liver of treated rats; however, the incidence of hepatocellular neoplasms was the same in treated and control rats.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

CNS depressant activity was demonstrated after acute i.p. administration of 150-300 mg/kg to mice.
Route of Administration: Intraperitoneal
Name Type Language
CYPROXIMIDE
USAN  
USAN  
Official Name English
1-(P-CHLOROPHENYL)-1,2-CYCLOPROPANEDICARBOXIMIDE
Common Name English
3-AZABICYCLO(3.1.0)HEXANE-2,4-DIONE, 1-(4-CHLOROPHENYL)-
Systematic Name English
CL-53415
Code English
CL 53415
Code English
CYPROXIMIDE [USAN]
Common Name English
CIPROXIMIDE
INN  
INN  
Official Name English
ciproximide [INN]
Common Name English
Code System Code Type Description
EVMPD
SUB07476MIG
Created by admin on Sat Dec 16 17:55:14 UTC 2023 , Edited by admin on Sat Dec 16 17:55:14 UTC 2023
PRIMARY
ChEMBL
CHEMBL2104097
Created by admin on Sat Dec 16 17:55:14 UTC 2023 , Edited by admin on Sat Dec 16 17:55:14 UTC 2023
PRIMARY
FDA UNII
KE6K6JP8FP
Created by admin on Sat Dec 16 17:55:14 UTC 2023 , Edited by admin on Sat Dec 16 17:55:14 UTC 2023
PRIMARY
INN
2388
Created by admin on Sat Dec 16 17:55:14 UTC 2023 , Edited by admin on Sat Dec 16 17:55:14 UTC 2023
PRIMARY
CAS
15518-76-0
Created by admin on Sat Dec 16 17:55:14 UTC 2023 , Edited by admin on Sat Dec 16 17:55:14 UTC 2023
PRIMARY
SMS_ID
100000081543
Created by admin on Sat Dec 16 17:55:14 UTC 2023 , Edited by admin on Sat Dec 16 17:55:14 UTC 2023
PRIMARY
PUBCHEM
12719804
Created by admin on Sat Dec 16 17:55:14 UTC 2023 , Edited by admin on Sat Dec 16 17:55:14 UTC 2023
PRIMARY
EPA CompTox
DTXSID001030812
Created by admin on Sat Dec 16 17:55:14 UTC 2023 , Edited by admin on Sat Dec 16 17:55:14 UTC 2023
PRIMARY
NCI_THESAURUS
C175759
Created by admin on Sat Dec 16 17:55:14 UTC 2023 , Edited by admin on Sat Dec 16 17:55:14 UTC 2023
PRIMARY