URIDINE MONOPHOSPHATE DISODIUM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H11N2O9P.2Na
Molecular Weight	368.1449
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of URIDINE MONOPHOSPHATE DISODIUM

Structure Search

SMILES

[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])([O-])=O)N2C=CC(=O)NC2=O

InChI

InChIKey=KURVIXMFFSNONZ-WFIJOQBCSA-L

InChI=1S/C9H13N2O9P.2Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7-,8-;;/m1../s1

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
CDP-choline pathway 3 Target ID: GO:0006657 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16126180	Activator 1430

PubMed

Title	Date	PubMed
Inhibition of herpes simplex virus DNA polymerase by purine ribonucleoside monophosphates.	1986 Feb 5	3003073
Comparison between tryptophan methoxyindole and kynurenine metabolic pathways in normal and preterm neonates and in neonates with acute fetal distress.	1998 Jul	9703384
Infectious bronchitis virus nucleocapsid protein interactions with the 3' untranslated region of genomic RNA depend on uridylate bases.	2001	11774543
RNA editing: complexity and complications.	2002 Aug	12139607
Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status.	2003 Apr	12672918
TbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosome.	2003 Jun	12820966
The poliovirus 2C cis-acting replication element-mediated uridylylation of VPg is not required for synthesis of negative-sense genomes.	2003 Sep	12917456
cis-acting elements at opposite ends of the Citrus tristeza virus genome differ in initiation and termination of subgenomic RNAs.	2004 Apr 25	15063115
Complete cycles of bloodstream trypanosome RNA editing in vitro.	2004 Jun	15146075
Protein-protein interactions of the hyperthermophilic archaeon Pyrococcus horikoshii OT3.	2005	16356270
Mutational analysis of the SARS virus Nsp15 endoribonuclease: identification of residues affecting hexamer formation.	2005 Nov 11	16216269
A multispecies comparison of the metazoan 3'-processing downstream elements and the CstF-64 RNA recognition motif.	2006 Mar 16	16542450
RNA-protein interactions in assembled editing complexes in trypanosomes.	2007	17662838
Modulation of mRNA stability as a novel therapeutic approach.	2007 Apr	17320967
The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy.	2007 Jan 17	17234598
Identification of quorum sensing-related regulons in Vibrio vulnificus by two-dimensional gel electrophoresis and differentially displayed reverse transcriptase PCR.	2007 Jun	17506728
Sendai virus RNA polymerase scanning for mRNA start sites at gene junctions.	2007 Jun 5	17300823
Structural and enzymatic investigation of the Sulfolobus solfataricus uridylate kinase shows competitive UTP inhibition and the lack of GTP stimulation.	2007 Mar 13	17297917
Functional and structural insights revealed by molecular dynamics simulations of an essential RNA editing ligase in Trypanosoma brucei.	2007 Nov 14	18060084
Turkey coronavirus non-structure protein NSP15--an endoribonuclease.	2008	19023218
Identification of a bacterial-like HslVU protease in the mitochondria of Trypanosoma brucei and its role in mitochondrial DNA replication.	2008 Apr 18	18421378
Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products.	2008 Jan 8	18067323
Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein.	2008 Jun	18547518
Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion.	2008 Jun	18441050
Toward understanding the conformational dynamics of RNA ligation.	2009 Feb 3	19133737
Unique GTP-binding pocket and allostery of uridylate kinase from a gram-negative phytopathogenic bacterium.	2009 Jan 30	19059268
The Alveolate Perkinsus marinus: biological insights from EST gene discovery.	2010 Apr 7	20374649
Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1.	2010 Aug 24	20808768
The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.	2010 Jul 16	20451531
Identifying essential genes in bacterial metabolic networks with machine learning methods.	2010 May 3	20438628

Patents

Name

Type

Language

URIDINE MONOPHOSPHATE DISODIUM

Systematic Name

English

DISODIUM URIDINE MONOPHOSPHATE

Systematic Name

English

DISODIUM 5'-URIDYLATE

Common Name

English

5'-UMP

Common Name

English

5'-URIDYLIC ACID, DISODIUM SALT

Common Name

English

DISODIUM 5'-URIDYLATE [USP-RS]

Common Name

English

DISODIUM URIDINE PHOSPHATE

Official Name

English

5'-URIDYLIC ACID, SODIUM SALT (1:2)

Common Name

English

DISODIUM URIDINE PHOSPHATE [INCI]

Common Name

English

URIDINE 5' -MONOPHOSPHATE DISODIUM SALT

Common Name

English

NSC-20257

Code

English

URIDINE 5-MO-PHOS DISOD

Common Name

English

Disodium Uridine Monophosphate [WHO-DD]

Common Name

English

DISODIUM 5'-URIDYLATE [FCC]

Common Name

English

URIDINE 5'-MONOPHOSPHATE DISODIUM SALT

Common Name

English

5-UMP-2NA

Brand Name

English

Code System Code Type Description

RS_ITEM_NUM

1222400