MODECAINIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H28N2O3
Molecular Weight	368.4693
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC(=CC=C1O)C(=O)NC2=CC=CC=C2CCC3CCCCN3C

InChI

InChIKey=LBYXPDAENJSHDD-UHFFFAOYSA-N

InChI=1S/C22H28N2O3/c1-24-14-6-5-8-18(24)12-10-16-7-3-4-9-19(16)23-22(26)17-11-13-20(25)21(15-17)27-2/h3-4,7,9,11,13,15,18,25H,5-6,8,10,12,14H2,1-2H3,(H,23,26)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6799644 | https://www.ncbi.nlm.nih.gov/pubmed/6420542

Modecainide is a benzanilide derivative patented by American pharmaceutical company Bristol-Myers Co. as type Ic antiarrhythmic agent. Modecainide is a major metabolite of Encainide, a class Ic antiarrhythmic, with comparable antiarrhythmic activity. Modecainide is never marketed because of its frequent proarrhythmic side effects.

Originator

Approval Year

PubMed

Title	Date	PubMed
Comparative antiarrhythmic actions of encainide and its major metabolites.	1986-06	3092755
Effects of encainide and metabolites (MJ14030 and MJ9444) on canine cardiac Purkinje and ventricular fibers.	1982-02	6799644

Patents

Sample Use Guides

In Vivo Use Guide

50 mg, every 6 hours

Route of Administration: Oral

Name

Type

Language

MODECAINIDE

Official Name

English

MJ-14030

Preferred Name

English

BENZAMIDE, 4-HYDROXY-3-METHOXY-N-(2-(2-(1-METHYL-2-PIPERIDINYL)ETHYL)PHENYL)-, (±)-

Systematic Name

English

BENZAMIDE, 4-HYDROXY-3-METHOXY-N-(2-(2-(1-METHYL-2-PIPERIDINYL)ETHYL)PHENYL)-

Systematic Name

English

modecainide [INN]

Common Name

English

BMY-40327

Code

English

(±)-2'-(2-(1-METHYL-2-PIPERIDYL)ETHYL)VANILLANILIDE

Systematic Name

English

3-METHOXY-O-DESMETHYLENCAINIDE

Common Name

English

MODECAINIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793