Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H15N3O4 |
| Molecular Weight | 289.2866 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)C1=C(C)N(N=C1C)C2=CC(=CC=C2)[N+]([O-])=O
InChI
InChIKey=MSYGAHOHLUJIKV-UHFFFAOYSA-N
InChI=1S/C14H15N3O4/c1-4-21-14(18)13-9(2)15-16(10(13)3)11-6-5-7-12(8-11)17(19)20/h5-8H,4H2,1-3H3
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Q07343 Gene ID: 5142.0 Gene Symbol: PDE4B Target Organism: Homo sapiens (Human) |
33.0 nM [IC50] | ||
Target ID: Q08499|||Q8IVD2 Gene ID: 5144.0 Gene Symbol: PDE4D Target Organism: Homo sapiens (Human) |
21.0 nM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
Sample Use Guides
Measurement of phosphodiesterase activity takes advantage of the selective binding of 5'-AMP or 5'-GMP (and not cAMP or cGMP) to yttrium silicate beads with embedded scintillant. In an assay PDE is incubated with 50 nM 3H-cyclic nucleotide The assay is terminated by adding one-third volume of 5 mg/ml yttrium silicate beads in 18 mM zinc acetate/zinc sulfate solution. Compound 21 inhibits PDE4B (IC50 33 nM) and PDE4D (IC50 21 nM).
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DTXSID70349675
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656969
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346440-86-6
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SUBSTANCE RECORD
