Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C9H12BNO4 |
| Molecular Weight | 209.007 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H](CC1=CC=C(C=C1)B(O)O)C(O)=O
InChI
InChIKey=NFIVJOSXJDORSP-QMMMGPOBSA-N
InChI=1S/C9H12BNO4/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15/h1-4,8,14-15H,5,11H2,(H,12,13)/t8-/m0/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cell cycle dependence of boron uptake from two boron compounds used for clinical neutron capture therapy. | 2002 Dec 10 |
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| Improved treatment planning for boron neutron capture therapy for glioblastoma multiforme using fluorine-18 labeled boronophenylalanine and positron emission tomography. | 2002 Oct |
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| Mutagenic effect of borocaptate sodium and boronophenylalanine in neutron capture therapy. | 2002 Oct 1 |
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| Prognostic and therapeutic indicator of fluoroboronophenylalanine positron emission tomography in patients with gliomas. | 2003 Dec 1 |
|
| Biodistribution of a carborane-containing porphyrin as a targeting agent for Boron Neutron Capture Therapy of oral cancer in the hamster cheek pouch. | 2003 Mar |
|
| Boron neutron capture therapy of brain tumors: clinical trials at the finnish facility using boronophenylalanine. | 2003 Mar-Apr |
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| A critical assessment of boron neutron capture therapy: an overview. | 2003 Mar-Apr |
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| The early successful treatment of glioblastoma patients with modified boron neutron capture therapy. Report of two cases. | 2003 Nov |
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| Synchrotron radiation-based experimental determination of the optimal energy for cell radiotoxicity enhancement following photoelectric effect on stable iodinated compounds. | 2004 Aug 2 |
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| Accumulation of boron in human malignant glioma cells in vitro is cell type dependent. | 2004 Jul |
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| Delivery of (10)boron to oral squamous cell carcinoma using boronophenylalanine and borocaptate sodium for boron neutron capture therapy. | 2004 May |
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| Effectiveness of BNCT for recurrent head and neck malignancies. | 2004 Nov |
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| Boronated epidermal growth factor as a delivery agent for neutron capture therapy of EGF receptor positive gliomas. | 2004 Nov |
|
| Radiobiology of BNCT mediated by GB-10 and GB-10+BPA in experimental oral cancer. | 2004 Nov |
|
| The effect of dexamethasone on the uptake of p-boronophenylalanine in the rat brain and intracranial 9L gliosarcoma. | 2004 Nov |
|
| Neutron capture therapy of epidermal growth factor (+) gliomas using boronated cetuximab (IMC-C225) as a delivery agent. | 2004 Nov |
|
| MicroPET-based pharmacokinetic analysis of the radiolabeled boron compound [18F]FBPA-F in rats with F98 glioma. | 2004 Nov |
|
| Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors. | 2004 Sep 1 |
|
| Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages. | 2005 Dec |
|
| Optimized 1H MRS and MRSI methods for the in vivo detection of boronophenylalanine. | 2005 May |
|
| Therapeutic success of boron neutron capture therapy (BNCT) mediated by a chemically non-selective boron agent in an experimental model of oral cancer: a new paradigm in BNCT radiobiology. | 2006 Aug |
|
| Impact of intra-arterial administration of boron compounds on dose-volume histograms in boron neutron capture therapy for recurrent head-and-neck tumors. | 2006 Dec 1 |
|
| Capillary electrophoresis-electrospray mass spectrometry and HR-ICP-MS for the detection and quantification of 10B-boronophenylalanine (10B-BPA) used in boron neutron capture therapy. | 2006 Feb |
|
| Molecular targeting and treatment of EGFRvIII-positive gliomas using boronated monoclonal antibody L8A4. | 2006 Jun 15 |
|
| Early effects of boron neutron capture therapy on rat glioma models. | 2007 |
|
| Molecular targeting and treatment of an epidermal growth factor receptor-positive glioma using boronated cetuximab. | 2007 Feb 15 |
|
| Therapeutic effect of boron neutron capture therapy (BNCT) on field cancerized tissue: inhibition of DNA synthesis and lag in the development of second primary tumors in precancerous tissue around treated tumors in DMBA-induced carcinogenesis in the hamster cheek pouch oral cancer model. | 2007 Mar |
|
| Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: towards a novel therapy for liver metastases. | 2007 Oct |
|
| Application of drug delivery system to boron neutron capture therapy for cancer. | 2008 Apr |
|
| Comments to article: Henriksson R et al., Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA) Radiother Oncol (2008). | 2008 Aug |
|
| Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA). | 2008 Aug |
|
| An international dosimetry exchange for BNCT part II: computational dosimetry normalizations. | 2008 Dec |
|
| Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors. | 2009 Dec |
|
| Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma. | 2009 Dec 11 |
|
| Boron neutron capture therapy for newly diagnosed glioblastoma. | 2009 Jan |
|
| Boron neutron capture therapy of EGFR or EGFRvIII positive gliomas using either boronated monoclonal antibodies or epidermal growth factor as molecular targeting agents. | 2009 Jul |
|
| Boron neutron capture therapy at the crossroads: challenges and opportunities. | 2009 Jul |
|
| Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT. | 2009 Jul |
|
| In vitro neutron irradiation of glioma and endothelial cultured cells. | 2009 Jul |
|
| Calculations of dose distributions in the lungs of a rat model irradiated in the thermal column of the TRIGA reactor in Pavia. | 2009 Jul |
|
| Selective uptake of p-boronophenylalanine by osteosarcoma cells for boron neutron capture therapy. | 2009 Jul |
|
| Feasibility of boron neutron capture therapy for malignant spinal tumors. | 2009 Jul |
|
| Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: an experimental study that supports a potential new application of BNCT. | 2009 Jul |
|
| Boronophenylalanine uptake in C6 glioma model is dramatically increased by L-DOPA preloading. | 2009 Jul |
|
| Planned fractionated boron neutron capture therapy using epithermal neutrons for a patient with recurrent squamous cell carcinoma in the temporal bone: a case report. | 2009 Mar |
|
| Insight into the mechanisms underlying tumor response to boron neutron capture therapy in the hamster cheek pouch oral cancer model. | 2009 May |
|
| Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life. | 2009 May 13 |
|
| Aryl boronic acid inhibition of synthetic melanin polymerization. | 2010 Aug 1 |
|
| Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax. | 2010 Dec 2 |
|
| Early effect of boron neutron capture therapy mediated by boronophenylalanine (BPA-BNCT) on mast cells in premalignant tissue and tumors of the hamster cheek pouch. | 2010 May |
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76410-58-7
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150315
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SUB33568
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JSM63LV5MD
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DTXSID70227242
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100000127519
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
