U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C37H41N5O9S.2K.Pd
Molecular Weight 916.43
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PADELIPORFIN POTASSIUM

SMILES

[K+].[K+].[Pd++].CC[C@@H]1[C@@H](C)C2=CC3=C(C(C)=O)C(C)=C([N-]3)C=C4N=C([C@@H](CCC([O-])=O)[C@@H]4C)C(CC(=O)OC)=C5[N-]C(=CC1=N2)C(C)=C5C(=O)NCCS([O-])(=O)=O

InChI

InChIKey=AOSMIFSJINLACN-NAEAMVODSA-J
InChI=1S/C37H45N5O9S.2K.Pd/c1-8-22-17(2)25-16-30-33(21(6)43)19(4)27(40-30)14-26-18(3)23(9-10-31(44)45)35(41-26)24(13-32(46)51-7)36-34(37(47)38-11-12-52(48,49)50)20(5)28(42-36)15-29(22)39-25;;;/h14-18,22-23H,8-13H2,1-7H3,(H5,38,39,40,41,42,43,44,45,47,48,49,50);;;/q;2*+1;+2/p-4/t17-,18+,22-,23+;;;/m1.../s1

HIDE SMILES / InChI
Padeliporfin is a vascular-acting photosensitizer consisting of a water-soluble, palladium-substituted bacteriochlorophyll derivative with antineoplastic activity. After administration, the drug is activated locally when the tumor bed is exposed to low-power laser light; reactive oxygen species (ROS) are formed upon activation and ROS-mediated necrosis may occur at the site of interaction between the photosensitizer, light and oxygen. Padeliporfin is approved in Europe for the treatment of adult patients with previously untreated, unilateral, low-risk, adenocarcinoma of the prostate and is marketed under tradename TOOKAD.

Approval Year

Name Type Language
PADELIPORFIN POTASSIUM
USAN  
Official Name English
STAKEL
Brand Name English
Padeliporfin dipotassium [WHO-DD]
Common Name English
PADELIPORFIN (POTASSIUM)
Common Name English
Potassium (SP-4-2)-[(7S,8S,17R,18R)-13-acetyl-18-ethyl-7,8-dihydro-5-(2-methoxy-2-oxoethyl)-2,8,12,17-tetramethyl-3-[(2-sulfoethyl)carbamoyl]-21H,23H-porphine-7-propanoato(4-)-κN21,κN22,κN23,κN24]-palladate(2-) (2:1)
Systematic Name English
WST11 DIPOTASSIUM
Code English
PALLADATE(2-), ((7S,8S,17R,18R)-13-ACETYL-18-ETHYL-7,8-DIHYDRO-5-(2-METHOXY-2-OXOETHYL)-2,8,12,17-TETRAMETHYL-3-(((2-SULFOETHYL)AMINO)CARBONYL)-21H,23H-PORPHINE-7-PROPANOATO(4-)-.KAPPA.N21,.KAPPA.N22,.KAPPA.N23,.KAPPA.N24)-, POTASSIUM (1:2), (SP-4-2)-
Systematic Name English
PADELIPORFIN DIPOTASSIUM
Common Name English
WST-11 DIPOTASSIUM
Code English
PADELIPORFIN POTASSIUM [USAN]
Common Name English
PADELIPORFIN DI-POTASSIUM [MI]
Common Name English
Code System Code Type Description
USAN
HI-09
Created by admin on Sat Dec 16 14:45:25 GMT 2023 , Edited by admin on Sat Dec 16 14:45:25 GMT 2023
PRIMARY
MERCK INDEX
m12050
Created by admin on Sat Dec 16 14:45:25 GMT 2023 , Edited by admin on Sat Dec 16 14:45:25 GMT 2023
PRIMARY
SMS_ID
100000166789
Created by admin on Sat Dec 16 14:45:25 GMT 2023 , Edited by admin on Sat Dec 16 14:45:25 GMT 2023
PRIMARY
PUBCHEM
129629432
Created by admin on Sat Dec 16 14:45:25 GMT 2023 , Edited by admin on Sat Dec 16 14:45:25 GMT 2023
PRIMARY
NCI_THESAURUS
C175732
Created by admin on Sat Dec 16 14:45:25 GMT 2023 , Edited by admin on Sat Dec 16 14:45:25 GMT 2023
PRIMARY
FDA UNII
JQ72VD4XUL
Created by admin on Sat Dec 16 14:45:25 GMT 2023 , Edited by admin on Sat Dec 16 14:45:25 GMT 2023
PRIMARY
CAS
698393-30-5
Created by admin on Sat Dec 16 14:45:25 GMT 2023 , Edited by admin on Sat Dec 16 14:45:25 GMT 2023
PRIMARY