U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry MIXED
Molecular Formula C22H28NO3.Br
Molecular Weight 434.367
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PIPENZOLATE BROMIDE

SMILES

[Br-].CC[N+]1(C)CCCC(C1)OC(=O)C(O)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=XEDCWWFPZMHXCM-UHFFFAOYSA-M
InChI=1S/C22H28NO3.BrH/c1-3-23(2)16-10-15-20(17-23)26-21(24)22(25,18-11-6-4-7-12-18)19-13-8-5-9-14-19;/h4-9,11-14,20,25H,3,10,15-17H2,1-2H3;1H/q+1;/p-1

HIDE SMILES / InChI
Pipenzolate bromide (JB-323), an anticholinergic agent, which binds to muscarinic acetylcholine receptors as an antagonist. Pipenzolate bromide was studied as an antispasmodic agent, and to treat peptic ulcer.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Palliative
SINSPASMON

Approved Use

Effective in the treatment of peptic ulcer and coadjuvant in irritable bowel syndrome, spastic colon, mucosal colitis, acute enterocolitis, colic, pylorus spasm, regurgitation and other functional disorders of the gastrointestinal tract.
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Pharmacologic properties of N-ethyl-3-piperidyl benzilate methobromide (JB-323), a potent antispasmodic agent.
1954 Sep
Peptic ulcer management with JB 323 (piptal) a new anticholinergic.
1955 Mar
The treatment index of JB 323 (piptal) in peptic ulcer.
1957 Jan
Normal pregnancy outcome following inadvertent exposure to rosiglitazone, gliclazide, and atorvastatin in a diabetic and hypertensive woman.
2004 Jun
Patents

Patents

Sample Use Guides

for dog: orally active antispasmodic agent with an atropine-like action
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
PIPENZOLATE BROMIDE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
1-ETHYL-3-HYDROXY-1-METHYLPIPERIDINIUM BROMIDE BENZILATE
Systematic Name English
1-ETHYL-3-((HYDROXYDIPHENYLACETYL)OXY)-1-METHYLPIPERIDINIUM BROMIDE
Systematic Name English
PIPENZOLATE BROMIDE [MI]
Common Name English
PIPENZOLATE METHYLBROMIDE
Common Name English
pipenzolate bromide [INN]
Common Name English
Pipenzolate bromide [WHO-DD]
Common Name English
PIPTAL
Brand Name English
JB-323
Code English
NSC-4347
Code English
PIPERIDINIUM, 1-ETHYL-3-((2-HYDROXY-2,2-DIPHENYLACETYL)OXY)-1-METHYL-, BROMIDE (1:1)
Systematic Name English
PIPENZOLONE BROMIDE
Common Name English
N-ETHYL-3-PIPERIDYL BENZILATE METHOBROMIDE
Common Name English
PIPENZOLATE BROMIDE [MART.]
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL1619528
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
NSC
4347
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
NCI_THESAURUS
C170321
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
SMS_ID
100000081963
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
MERCK INDEX
m8843
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
204-741-2
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
RXCUI
202840
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY RxNorm
INN
652
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
EVMPD
SUB09864MIG
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
WIKIPEDIA
Pipenzolate bromide
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
FDA UNII
JPX41DUS2B
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
EPA CompTox
DTXSID2023480
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
CAS
125-51-9
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY
PUBCHEM
657306
Created by admin on Fri Dec 15 16:56:00 GMT 2023 , Edited by admin on Fri Dec 15 16:56:00 GMT 2023
PRIMARY