ISOQUINOLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H7N
Molecular Weight	129.1586
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1=CC2=CC=NC=C2C=C1

InChI

InChIKey=AWJUIBRHMBBTKR-UHFFFAOYSA-N

InChI=1S/C9H7N/c1-2-4-9-7-10-6-5-8(9)3-1/h1-7H

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Cis-[Pt(Cl)2(pyridine)(5-SO3H-isoquinoline)] complex, a selective inhibitor of telomerase enzyme.	2003-12	12779240
Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquinolines.	2003-07-18	12866710
Perspective in antimalarial chemotherapy.	2003-07	12678807
Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT).	2003-06-20	12798691
New strategy for the synthesis of tetrahydroisoquinoline alkaloids.	2003-06-12	12790559
Beta-phenylethylamines and the isoquinoline alkaloids.	2003-06	12828372
Super acid-induced Pummerer-type cyclization reaction: improvement in the synthesis of chiral 1,3-dimethyl-1,2,3,4-tetrahydroisoquinolines.	2003-06	12808244
Novel high energy intermediate analogues with triazasterol-related structures as inhibitors of ergosterol biosynthesis. III. Synthesis and antifungal activity of N4-alkyl-1,6,7,11b-tetrahydro-2H-pyrimido[4,3-a]isoquinolin-4-amine salts.	2003-06	12791418
Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines.	2003-05-15	12713840
Antitrypanosomal naphthylisoquinoline alkaloids and related compounds.	2003-05	12779053
Benzoquinolines and chloride secretion in murine colonic epithelium.	2003-04	12721108
A new isoquinolinone derivative with noble vasorelaxation activity.	2003-04	12595751
[Genetic aspects of the relationship between isoquinoline alkaloids and mineral elements in greater celandine (Chelidonium majus L.)].	2003-03-11	12625040
In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis.	2003-03	12672149
Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design.	2003-03	12657723
Mode of binding of the cytotoxic alkaloid berberine with the double helix oligonucleotide d(AAGAATTCTT)(2).	2003-02-20	12538015
Synthesis of 4-(1-alkenyl)isoquinolines by palladium(II)-catalyzed cyclization/olefination.	2003-02-07	12558424
A short diastereoselective synthesis of the putative alkaloid jamtine, using a tandem pummerer/mannich cyclization sequence.	2003-02-07	12558418
Suppression of tumor necrosis factor-alpha and inducible nitric oxide synthase gene expression by THI 52, a new synthetic naphthyl-benzylisoquinoline alkaloid.	2003-02-01	12527339
In vitro anti-influenza virus activity of isoquinoline alkaloids from thalictrum species.	2003-02	12624821
Unexpected isolation, and structural characterization, of a beta-hydrogen-containing sigma-alkylpalladium halide complex in the course of an intramolecular heck reaction. synthesis of polycyclic isoquinoline derivatives.	2003-01-21	12585426
A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species.	2002-12-27	12467905
Direct determination of alkaloid contents in Fumaria species by GC-MS.	2002-12-24	12494757
Inhibitory effect of isoquinoline alkaloids on movement of second-stage larvae of Toxocara canis.	2002-12	12499659
Cobalt(II) and nickel(II) complexes of isoquinoline-1-carboxylate.	2002-12	12466602
Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids.	2002-11-20	12428952
Constituents from the root and stem of Aristolochia elegans.	2002-11	12444670
Immunocytological localization of two enzymes involved in berberine biosynthesis.	2002-11	12430014
Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells.	2002-11	12423366
An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines.	2002-11	12393141
A novel three-component reaction for the diastereoselective synthesis of 2H-pyrimido[2,1-a]isoquinolines via 1,4-dipolar cycloaddition.	2002-10-17	12375891
Determination of a new isoquinolinedione derivative, 7-anilino-5,8-isoquinolinedione, in plasma, urine and tissue homogenates by high-performance liquid chromatography.	2002-10-15	12367676
AlCl(3) x 6H(2)O/KI/H(2)O/CH(3)CN: a new alternate system for dehydration of oximes and amides in hydrated media.	2002-10-04	12354011
Synthesis of 3-substituted 4-aroylisoquinolines via Pd-catalyzed carbonylative cyclization of 2-(1-alkynyl)benzaldimines.	2002-10-04	12353998
Inhibitory activity on binding of specific ligands to the human angiotensin II AT(1) and endothelin 1 ET(A) receptors: bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens.	2002-09	12357384
Molecular modeling of 3-arylisoquinoline antitumor agents active against A-549. A comparative molecular field analysis study.	2002-09	12110317
Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease.	2002-08-30	12200189
Potential neurotoxic "agents provocateurs" in Parkinson's disease.	2002-08-30	12200188
Tandem Pummerer/Mannich cyclization cascade of alpha-sulfinylamides as a method to prepare aza-heterocycles.	2002-08-23	12182624
Synthesis of fluoren-9-ones by the palladium-catalyzed cyclocarbonylation of o-halobiaryls.	2002-08-09	12153259
Drotaverine interacts with the L-type Ca(2+) channel in pregnant rat uterine membranes.	2002-08-02	12163106
Presence of isoquinoline alkaloids in molluscan ganglia.	2002-08	12195236
First total synthesis of a novel monoterpenoid isoquinoline alkaloid, (+/-)-alangine.	2002-08	12192157
Two optically active isoquinoline derivatives.	2002-08	12154312
Bulk weak ferromagnet in ferrimagnetic chains of organic-inorganic hybrid materials based on BDH-TTP and paramagnetic thiocyanato complex anions: (BDH-TTP)[M(isoq)(2)(NCS)(4)], M = Cr(III), Fe(III).	2002-07-15	12099885
Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells.	2002-07	12100750
Beta-phenylethylamines and the isoquinoline alkaloids.	2002-06	12137281
PK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro.	2002	12382020
Synthesis of aza-heterocycles from oximes by amino-Heck reaction.	2002	12203909
A(3) adenosine receptor antagonists.	2001-11	12369967

Patents

Name

Type

Language

ISOQUINOLINE

Systematic Name

English

NSC-3395

Preferred Name

English

FEMA NO. 2978

Code

English

ISOQUINOLINE [FHFI]

Common Name

English

LEUCOLINE

Common Name

English

BETA-QUINOLINE

Common Name

English

ISOQUINOLINE [MI]

Common Name

English

2-BENZAZINE

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

ISOQUINOLINE