Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H16F4N4O3S |
| Molecular Weight | 492.446 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC(=O)C1=C(F)C=C(C=C1)N2C(=S)N(C(=O)[C@]23CCOC3)C4=CC=C(C#N)C(=C4)C(F)(F)F
InChI
InChIKey=QKKPJFTYJCXESR-OAQYLSRUSA-N
InChI=1S/C22H16F4N4O3S/c1-28-18(31)15-5-4-14(9-17(15)23)30-20(34)29(19(32)21(30)6-7-33-11-21)13-3-2-12(10-27)16(8-13)22(24,25)26/h2-5,8-9H,6-7,11H2,1H3,(H,28,31)/t21-/m1/s1
Approval Year
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77461273
Created by
admin on Sat Dec 16 11:55:28 GMT 2023 , Edited by admin on Sat Dec 16 11:55:28 GMT 2023
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1351185-54-0
Created by
admin on Sat Dec 16 11:55:28 GMT 2023 , Edited by admin on Sat Dec 16 11:55:28 GMT 2023
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ONC1-13B
Created by
admin on Sat Dec 16 11:55:28 GMT 2023 , Edited by admin on Sat Dec 16 11:55:28 GMT 2023
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PRIMARY | MedKoo CAT NO.: 206711, CAS NO.: 1351185-54-0Description: ONC1-13B is an antagonist of androgen receptor, with similar to MDV3100 and ARN-509 mechanism of action. ONC1-13B efficiently inhibits DHT-stimulated PSA expression and proliferation of prostate cancer cells, prevents binding of androgens to the AR ligand-binding domain, androgen-stimulated AR nuclear translocation and co-activator complex formation. In the LnCaP-Z2 xenograft model of prostate cancer ONC1-13B inhibits tumor growth and suppresses PSA expression. Thus ONC1-13B is a new promising anti-androgen demonstrating high efficacy in a preclinical model of prostate cancer, with lower potential for seizures and drug-drug interaction. (last updated: 4/16/2016)Synonym: ONC1-13B, ONC113B, ONC 113B, ONC1-0013B, ONC 10013B, ONC-10013B.IUPAC/Chemical Name: (R)-4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-4-oxo-2-thioxo-7-oxa-1,3-diazaspiro(4.4)nonan-1-yl)-2-fluoro-N-methylbenzamide | ||
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C148485
Created by
admin on Sat Dec 16 11:55:28 GMT 2023 , Edited by admin on Sat Dec 16 11:55:28 GMT 2023
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JFG7JWH6YL
Created by
admin on Sat Dec 16 11:55:28 GMT 2023 , Edited by admin on Sat Dec 16 11:55:28 GMT 2023
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PRIMARY |
ACTIVE MOIETY
