Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H20Cl4N2 |
| Molecular Weight | 358.134 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 2 |
SHOW SMILES / InChI
SMILES
C[N+](C)(C)CC[N+]1(C)CC2=C(C1)C(Cl)=C(Cl)C(Cl)=C2Cl
InChI
InChIKey=IXWDUZLHWJKVPX-UHFFFAOYSA-N
InChI=1S/C14H20Cl4N2/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15/h5-8H2,1-4H3/q+2
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Influences of the corticotropic axis and sympathetic activity on neurochemical consequences of 3,4-methylenedioxymethamphetamine (MDMA) administration in Fischer 344 rats. | 2002 Aug |
|
| Influence of cytisine on catecholamine release in isolated perfused rat adrenal glands. | 2002 Dec |
|
| Isoflurane hyperalgesia is modulated by nicotinic inhibition. | 2002 Jul |
|
| Cardiovascular and behavioural components of conditioned fear to context after ganglionic and alpha-adrenergic blockade. | 2002 Jun 28 |
|
| Heteromeric nicotinic inhibition by isoflurane does not mediate MAC or loss of righting reflex. | 2002 Oct |
|
| Subclinical doses of the nerve gas sarin impair T cell responses through the autonomic nervous system. | 2002 Oct 15 |
|
| Effects of nicotine on memory impairment induced by blockade of muscarinic, nicotinic and dopamine D2 receptors in rats. | 2003 Aug 8 |
|
| Effect of intravenous angiotensin II infusion on responses to hypothalamic PVN injection of bicuculline. | 2003 Dec |
|
| Effect of (+/-)-epibatidine, a nicotinic agonist, on the central pathways controlling voiding function in the rat. | 2003 Jul |
|
| Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain. | 2003 Jun |
|
| Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock. | 2003 Mar 4 |
|
| Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor. | 2003 Mar-Apr |
|
| An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice. | 2003 Sep |
|
| Effect of a perinatal high-salt diet on blood pressure control mechanisms in young Sprague-Dawley rats. | 2004 Apr |
|
| Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. | 2004 Feb |
|
| Cardiovascular effects of nicotine, chlorisondamine, and mecamylamine in the pigeon. | 2004 Jan |
|
| The interaction between the cholinergic and dopaminergic system in learning and memory process in rats. | 2004 Jan-Jun |
|
| Mechanism of action of A-85380 in an animal model of depression. | 2004 Jul |
|
| Central but not the peripheral action of cholinergic compounds suppresses the immune system. | 2004 Mar |
|
| Mechanisms and significance of the increased brain uptake of tryptophan. | 2005 Dec |
|
| Vasodilatation of the hindquarters induced by antagonism of GABA(A) receptors in the freely moving rat. | 2005 Feb |
|
| Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS. | 2005 Feb |
|
| Localization and analyses of small drug molecules in rat brain tissue sections. | 2005 Oct 15 |
|
| Intracellular cGMP may promote Ca2+-dependent and Ca2+-independent release of catecholamines from sympathetic nerve terminals. | 2006 Aug |
|
| Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors. | 2006 Jul |
|
| CCCP enhances catecholamine release from the perfused rat adrenal medulla. | 2006 Jul 30 |
|
| Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock. | 2006 May |
|
| Role of beta-endorphin, corticotropin-releasing hormone, and autonomic nervous system in mediation of the effect of chronic ethanol on natural killer cell cytolytic activity. | 2006 Oct |
|
| Effect of a diterpenoid from Salvia cinnabarina on arterial blood pressure in rats. | 2007 Jul |
|
| Long- and short-term changes in the neuroimmune-endocrine parameters following inhalation exposures of F344 rats to low-dose sarin. | 2007 May |
|
| Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII. | 2007 Oct |
|
| What's new in Nicotine & Tobacco Research? | 2007 Sep |
|
| Morphine and ABT-594 (a nicotinic acetylcholine agonist) exert centrally mediated antinociception in the rat cyclophosphamide cystitis model of visceral pain. | 2008 Feb |
|
| Effects of dipeptidyl peptidase iv inhibition on arterial blood pressure. | 2008 Jan |
|
| Prenatal high salt programs enhanced sympathoadrenal activation of the cardiovascular response to restraint. | 2009 Oct 5 |
|
| The effect of restraint stress on glucocorticoid receptors in mouse spleen lymphocytes: involvement of the sympathetic nervous system. | 2010 |
|
| Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. | 2010 Aug 12 |
|
| Lipid-enriched enteral nutrition controls the inflammatory response in murine Gram-negative sepsis. | 2010 Oct |
Sample Use Guides
In cultured dissociated mesencephalic cells of the fetal rat, chlorisondamine inhibited [3H]-dopamine release evoked by N-methyl-D-aspartate (10^-4 M), but only at high concentrations (IC50 approx. 600 microM). A high concentration of chlorisondamine (10^-3 M) had no effect on responses to quisqualate (10^-5 M) and only slightly reduced responses to kainate (10^-4 M). In adult rat hippocampal slices, chlorisondamine depressed NMDA receptor-mediated synaptically-evoked field potentials, but again only at high concentrations (10^-4-10^-3 M). Synaptic responses that were mediated by non-NMDA excitatory amino acid receptors were less affected.
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C66886
Created by
admin on Fri Dec 15 17:24:40 GMT 2023 , Edited by admin on Fri Dec 15 17:24:40 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
7701-62-4
Created by
admin on Fri Dec 15 17:24:39 GMT 2023 , Edited by admin on Fri Dec 15 17:24:39 GMT 2023
|
PRIMARY | |||
|
JD3M24F66I
Created by
admin on Fri Dec 15 17:24:40 GMT 2023 , Edited by admin on Fri Dec 15 17:24:40 GMT 2023
|
PRIMARY | |||
|
DTXSID0048395
Created by
admin on Fri Dec 15 17:24:39 GMT 2023 , Edited by admin on Fri Dec 15 17:24:39 GMT 2023
|
PRIMARY | |||
|
CHLORISONDAMINE
Created by
admin on Fri Dec 15 17:24:40 GMT 2023 , Edited by admin on Fri Dec 15 17:24:40 GMT 2023
|
PRIMARY | |||
|
D002714
Created by
admin on Fri Dec 15 17:24:40 GMT 2023 , Edited by admin on Fri Dec 15 17:24:40 GMT 2023
|
PRIMARY | |||
|
598
Created by
admin on Fri Dec 15 17:24:39 GMT 2023 , Edited by admin on Fri Dec 15 17:24:39 GMT 2023
|
PRIMARY | |||
|
C83619
Created by
admin on Fri Dec 15 17:24:40 GMT 2023 , Edited by admin on Fri Dec 15 17:24:40 GMT 2023
|
PRIMARY | |||
|
6244
Created by
admin on Fri Dec 15 17:24:40 GMT 2023 , Edited by admin on Fri Dec 15 17:24:40 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
