MELPERONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H22FNO
Molecular Weight	263.3504
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1

InChI

InChIKey=DKMFBWQBDIGMHM-UHFFFAOYSA-N

InChI=1S/C16H22FNO/c1-13-8-11-18(12-9-13)10-2-3-16(19)14-4-6-15(17)7-5-14/h4-7,13H,2-3,8-12H2,1H3

HIDE SMILES / InChI

Description
Sources: http://www.ratiopharm.de/index.php?eID=dumpFile&t=f&f=60721&g=-1&r=1894%2C1894&token=c00130080812868362409a3ab52b4a122b2af3ad

Melperone is an antipsychotic drug which is used in Europe for the treatment of sleep disorders, agitation and confusion states. The exact mechanism of melperone action is unknown.

CNS Activity

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Sleep disorder 20 Sources: http://www.ratiopharm.de/index.php?eID=dumpFile&t=f&f=60721&g=-1&r=1894%2C1894&token=c00130080812868362409a3ab52b4a122b2af3ad	Primary	Approved 8429	MELPERON Approved Use Melperon is used to treat sleep disorders, confusion states, and to suppress psychomotor restlessness and excitement, especially in geriatric and psychiatric patients.
Confusional state 2 Sources: http://www.ratiopharm.de/index.php?eID=dumpFile&t=f&f=60721&g=-1&r=1894%2C1894&token=c00130080812868362409a3ab52b4a122b2af3ad	Primary	Approved 8429	MELPERON Approved Use Melperon is used to treat sleep disorders, confusion states, and to suppress psychomotor restlessness and excitement, especially in geriatric and psychiatric patients.
Psychomotor agitation 6 Sources: http://www.ratiopharm.de/index.php?eID=dumpFile&t=f&f=60721&g=-1&r=1894%2C1894&token=c00130080812868362409a3ab52b4a122b2af3ad	Primary	Approved 8429	MELPERON Approved Use Melperon is used to treat sleep disorders, confusion states, and to suppress psychomotor restlessness and excitement, especially in geriatric and psychiatric patients.

PubMed

Title	Date	PubMed
Melperone in the treatment of neuroleptic-resistant schizophrenia.	2001 Dec 31	11814539
Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series.	2006 Feb 28	16507108
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose of melperone (in form of hydrochloride salt) is 25-75 mg/day. In the case of restless and confused patients the drug is given at a dose of 50-100 mg at the beginning of the treatment. The dose can be increased up to 200 mg if necessary. In severe disorders of confusion and confusion with aggression and hallucinatory conditions, the daily dose can be increased to up to 400 mg melperone HCl.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

MELPERONE

Official Name

English

METYLPERON

Common Name

English

MELPERONE [MI]

Common Name

English

Melperone [WHO-DD]

Common Name

English

melperone [INN]

Common Name

English

BUNIL

Brand Name

English

FG 5111

Code

English

FG-5111

Code

English

4'-FLUORO-4-(4-METHYLPIPERIDINO)BUTYROPHENONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710