U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C12H15F2NO2
Molecular Weight 243.2498
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MANIFAXINE

SMILES

C[C@@H]1CO[C@](O)([C@H](C)N1)C2=CC(F)=CC(F)=C2

InChI

InChIKey=OZGPVYJHWWPEFT-RGNHYFCHSA-N
InChI=1S/C12H15F2NO2/c1-7-6-17-12(16,8(2)15-7)9-3-10(13)5-11(14)4-9/h3-5,7-8,15-16H,6H2,1-2H3/t7-,8+,12-/m1/s1

HIDE SMILES / InChI
Manifaxine (GW 320659) is a highly selective neuronal norepinephrine and dopamine re-uptake inhibitor. It has been in phase II clinical trials by GlaxoSmithKline for the treatment of attention deficit hyperactivity disorder and obesity. Manifaxine development has been discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
The impact of medications on quality of life in attention-deficit hyperactivity disorder: a systematic review.
2010 Oct

Sample Use Guides

a multicenter, open-label, dose-titration study of seven daily dose levels of manifaxine (GW 320659): 1.25, 2.5, 5, 7.5,10,12.5, and 15 mg.
Route of Administration: Unknown
Name Type Language
MANIFAXINE
INN  
INN  
Official Name English
(2S,3S,5R)-2-(3,5-DIFLUOROPHENYL)-3,5-DIMETHYLMORPHOLIN-2-OL
Systematic Name English
manifaxine [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29747
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
NCI_THESAURUS C66884
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID60928953
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
PRIMARY
NCI_THESAURUS
C81329
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
PRIMARY
INN
8088
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
PRIMARY
SMS_ID
300000037021
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
PRIMARY
FDA UNII
J8IE53G2IV
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
PRIMARY
CAS
135306-39-7
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106783
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
PRIMARY
WIKIPEDIA
MANIFAXINE
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
PRIMARY
PUBCHEM
60829
Created by admin on Sat Dec 16 16:54:57 GMT 2023 , Edited by admin on Sat Dec 16 16:54:57 GMT 2023
PRIMARY