Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | H2O4W |
| Molecular Weight | 249.85 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O[W](O)(=O)=O
InChI
InChIKey=CMPGARWFYBADJI-UHFFFAOYSA-L
InChI=1S/2H2O.2O.W/h2*1H2;;;/q;;;;+2/p-2
Tungstic acid is a fairly strong acid, it catalyzes the oxidation by hydrogen peroxide of alkenes to the corresponding epoxides. Tungstic acid is widely used in the production of tungsten metal, alloys, and is used as a mordant for textiles and plastics. Tungstic acid has been reported to
rapidly precipitate the quaternary ammonium cations in cholinergic nerve terminals, such as ACh or choline. Also, tungsten dietary supplementation has successfully
been used to reduce xanthine oxide (XO) activity,
resulting in decreased gastrointestinal (GI) mucosal damage because of lowered XO activity. Tungstic acid has been shown to effectively antagonize stress-induced gastric ulcers, possibly by decreasing motility and mass cell degranulation. Tungstic acid gel has been used as an epileptogenic agent since 1960. Epilepsy produced by this agent is characterized by good localization, short latency and limited duration. It is effective in cerebral cortex, brain stem and spinal cord.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The preparation of tungstic acid gel and its use in the production of experimental epilepsy. | 1967 Mar |
|
| Streamline pattern and velocity components of flow in a model of a branching coronary vessel--possible functional implication for the development of localized platelet deposition in vitro. | 1986 Mar |
|
| Tungstic acid reduction of cold-resistant stress-induced ulceration in rats. | 1997 Jan |
|
| Protective effects of tungstophosphoric acid and sodium tungstate on chemically induced liver necrosis in wistar rats. | 2007 |
|
| The potential reproductive, neurobehavioral and systemic effects of soluble sodium tungstate exposure in Sprague-Dawley rats. | 2011 Jul 15 |
|
| Exposure to sodium tungstate and Respiratory Syncytial Virus results in hematological/immunological disease in C57BL/6J mice. | 2012 Apr 5 |
|
| Genotoxic changes to rodent cells exposed in vitro to tungsten, nickel, cobalt and iron. | 2014 Mar 10 |
|
| Tungsten-induced carcinogenesis in human bronchial epithelial cells. | 2015 Oct 1 |
Sample Use Guides
Sprague-Dawley rats were restrained at 4 degrees C for 2 h (stress). Tungstic acid in a single dose of 0.01, 0.1, 1, 10, 100 or 300 mg/kg (dissolved in distilled water) was administered intragastrically to animals 30 min prior to stress. Doses of tungstic acid of 1 mg/kg and higher significantly decreased ulcers.
Route of Administration:
Intragastric
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DTXSID80894161
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1152
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231-975-2
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m11268
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TUNGSTIC ACID
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7783-03-1
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36272
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SUBSTANCE RECORD
