ZINC

Details

Stereochemistry	ACHIRAL
Molecular Formula	Zn
Molecular Weight	65.409
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

[Zn]

InChI

InChIKey=HCHKCACWOHOZIP-UHFFFAOYSA-N

InChI=1S/Zn

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Description

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
C55-isoprenyl pyrophosphate 7	Binding Agent 1,064

Conditions

Condition	Modality	Highest Phase	Product
Infection 7	Curative	Approved 8,429	BACITRACIN
Skin diseases 10	Curative	Approved 8,429	CORTISPORIN
Superficial infections of the external eye and its adnexa caused by susceptible bacteria 5	Curative	Approved 8,429	NEOSPORIN

PubMed

Show entries

Title	Date	PubMed
A Note on the Susceptibility of Hemophilus influenzae Type B to Bacitracin.	1948 Oct	16561599
In vitro sensitivity of Bacillus proteus and Pseudomonas aeruginosa to seven antibiotics; penicillin, streptomycin, bacitracin, polymyxin, aerosporin, aureomycin, and chloromycetin.	1950 Feb	15404235
Systemic bacitracin in the treatment of progressive bacterial synergistic gangrene.	1950 Feb	15402788
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.	1992 Dec	1304235
Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes.	1992 Jul 15	1321133