Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C35H56N10O15 |
| Molecular Weight | 856.8771 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 12 / 12 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H](O)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](C)N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(N)=O
InChI
InChIKey=AKWRNBWMGFUAMF-ZESMOPTKSA-N
InChI=1S/C35H56N10O15/c1-13(36)29(54)41-22(12-46)32(57)43-26(16(4)49)34(59)45-27(17(5)50)35(60)44-25(15(3)48)33(58)40-21(11-23(37)52)30(55)39-20(10-18-6-8-19(51)9-7-18)31(56)42-24(14(2)47)28(38)53/h6-9,13-17,20-22,24-27,46-51H,10-12,36H2,1-5H3,(H2,37,52)(H2,38,53)(H,39,55)(H,40,58)(H,41,54)(H,42,56)(H,43,57)(H,44,60)(H,45,59)/t13-,14-,15-,16-,17-,20+,21+,22+,24+,25+,26+,27+/m1/s1
DAPTA (D-ala-peptide T-amide) is a synthetic peptide that prevents HIV entry by blocking binding of HIV gp120 protein with CCR5 receptor. In a small clinical study of internasal formulation of DAPTA in long-term infected HIV patients, administration of DAPTA led to decrease in the amount of virus isolated from white blood cells, an increase in gamma-interferon secreting T-cells in the absense of drug-related toxicity. In another clinical study DAPTA in combination with antiretroviral therapy reduced the peripheral (plasma and serum) viral load, but did not reduce the CSF viral load.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity. | 1986 Dec |
|
| Peptide T[4-8] is core HIV envelope sequence required for CD4 receptor attachment. | 1987 Sep 26 |
|
| Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). | 2005 Aug |
Patents
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| Code System | Code | Type | Description | ||
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106362-34-9
Created by
admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
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PRIMARY | |||
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J208V4ZMP2
Created by
admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
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PRIMARY | |||
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184644
Created by
admin on Fri Dec 15 15:38:45 GMT 2023 , Edited by admin on Fri Dec 15 15:38:45 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
