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Details

Stereochemistry ABSOLUTE
Molecular Formula C14H22N6O5.ClH
Molecular Weight 390.823
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VALGANCICLOVIR HYDROCHLORIDE, (S)-

SMILES

Cl.CC(C)[C@H](N)C(=O)OC[C@H](CO)OCN1C=NC2=C1N=C(N)NC2=O

InChI

InChIKey=ZORWARFPXPVJLW-OZZZDHQUSA-N
InChI=1S/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8-,9-;/m0./s1

HIDE SMILES / InChI

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Cytomegalovirus infection in immunocompetent and immunocompromised individuals--a review.
2001 Aug
Cytomegalovirus infection: the point in 2001.
2001 Oct
Valganciclovir: A new oral alternative for cytomegalovirus retinitis in human immunodeficiency virus-seropositive individuals.
2002 Sep
Valganciclovir: a new treatment for cytomegalovirus retinitis.
2002 Winter
Cytomegalovirus prophylaxis with valganciclovir in kidney, pancreas-kidney, and pancreas transplantation.
2004 Aug
Valganciclovir for the prevention and treatment of cytomegalovirus disease in immunocompromised hosts.
2004 Feb
A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein.
2004 Mar-Apr
Valganciclovir for the prophylaxis of cytomegalovirus disease in pediatric liver transplant recipients.
2004 May 15
Pre-emptive treatment with oral valganciclovir in management of CMV infection after cardiac transplantation.
2004 Nov
Cytomegalovirus retinitis in a patient treated with anti-tumor necrosis factor alpha antibody therapy for rheumatoid arthritis.
2004 Nov 1
Valganciclovir prophylaxis in patients at high risk for the development of cytomegalovirus disease.
2004 Sep
Cytomegalovirus retinitis in an immunocompetent patient.
2005 Apr
Pharmacokinetics of antiviral agents for the treatment of cytomegalovirus infection.
2005 Apr 15
[Valganciclovir maintenance therapy in AIDS: treatment failure due to the development of cytomegalovirus resistance to ganciclovir].
2005 Feb
Initial experience with oral valganciclovir for pre-emptive cytomegalovirus therapy after lung transplantation.
2005 Jul
Cytomegalovirus colitis mimicking ischemic colitis in an immunocompetent host.
2005 Jul-Aug
Successful treatment of mediastinal lymphomatoid granulomatosis with rituximab monotherapy.
2005 Mar
Clinical utility of cytomegalovirus (CMV) serology testing in high-risk CMV D+/R- transplant recipients.
2005 May
Patents
Name Type Language
VALGANCICLOVIR HYDROCHLORIDE, (S)-
Common Name English
L-VALINE, 2-((2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY)-3-HYDROXYPROPYL ESTER, MONOHYDROCHLORIDE, (S)-
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID40170034
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
PUBCHEM
135565147
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
CAS
175865-61-9
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
FDA UNII
J0IEW0BSHV
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY